Publication: Antimicrobial activity of rhodomyrtone isolated from Rhodomyrtus tomentosa (Aiton) Hassk
1
Issued Date
2018-01-01
ISSN
14786427
14786419
14786419
Other identifier(s)
2-s2.0-85059578842
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Natural Product Research. (2018)
Suggested Citation
Quynh N. Bach, Sakchai Hongthong, Lien T. Quach, Lieu V. Pham, Thuc V. Pham, Chutima Kuhakarn, Vichai Reutrakul, Phuong T.M. Nguyen Antimicrobial activity of rhodomyrtone isolated from Rhodomyrtus tomentosa (Aiton) Hassk. Natural Product Research. (2018). doi:10.1080/14786419.2018.1540479 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/44908
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Title
Antimicrobial activity of rhodomyrtone isolated from Rhodomyrtus tomentosa (Aiton) Hassk
Abstract
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. Rhodomyrtone was isolated from the leaves of Rhodomyrtus tomentosa (Aiton) Hassk grown in Vietnam using chromatographic methods. Its chemical structure was confirmed by means of spectroscopic data analysis. The pH drop measurement, enzyme activity assays and fluorescence stain were used to examine rhodomyrtone anticaries activity. It was found that rhodomyrtone suppressed acid production by Streptococcus mutans, a major cariogenic agent in human by inhibiting enzyme activities responsible for acid production and tolerance, including membrane bound enzymes F-ATPase and phosphotransferase system (PTS), as well as glycolysis enzymes glyceraldehyphosphate dehydrogenase (GAPDH) and pyruvate kinase (PK) in cytoplasm with the IC50 values of 24 μM, 19 μM, 23 μM and 28 μM, respectively. Moreover, 50 μM rhodomyrtone reduced biofilm biomass formed by S. mutans up to 59% (p < 0.05). Fluorescent images indicated that cells on the biofilms were significantly killed. Thus, rhodomyrtone is a new and potential anticaries agent against S. mutans.