Publication:
Phantom design and dosimetric characterization for multiple simultaneous cell irradiations with active pencil beam scanning

dc.contributor.authorMonika Clausenen_US
dc.contributor.authorSuphalak Khachonkhamen_US
dc.contributor.authorSylvia Gruberen_US
dc.contributor.authorPeter Kuessen_US
dc.contributor.authorRolf Seemannen_US
dc.contributor.authorBarbara Knäuslen_US
dc.contributor.authorElisabeth Maraen_US
dc.contributor.authorHugo Palmansen_US
dc.contributor.authorWolfgang Dörren_US
dc.contributor.authorDietmar Georgen_US
dc.contributor.otherEBG MedAustron GmbHen_US
dc.contributor.otherFaculty of Medicine, Ramathibodi Hospital, Mahidol Universityen_US
dc.contributor.otherMedizinische Universitat Wienen_US
dc.contributor.otherNational Physical Laboratoryen_US
dc.contributor.otherUniversity of Applied Scienceen_US
dc.date.accessioned2020-01-27T07:37:01Z
dc.date.available2020-01-27T07:37:01Z
dc.date.issued2019-11-01en_US
dc.description.abstract© 2019, The Author(s). A new phantom was designed for in vitro studies on cell lines in horizontal particle beams. The phantom enables simultaneous irradiation at multiple positions along the beam path. The main purpose of this study was the detailed dosimetric characterization of the phantom which consists of various heterogeneous structures. The dosimetric measurements described here were performed under non-reference conditions. The experiment involved a CT scan of the phantom, dose calculations performed with the treatment planning system (TPS) RayStation employing both the Pencil Beam (PB) and Monte Carlo (MC) algorithms, and proton beam delivery. Two treatment plans reflecting the typical target location for head and neck cancer and prostate cancer treatment were created. Absorbed dose to water and dose homogeneity were experimentally assessed within the phantom along the Bragg curve with ionization chambers (ICs) and EBT3 films. LETd distributions were obtained from the TPS. Measured depth dose distributions were in good agreement with the Monte Carlo-based TPS data. Absorbed dose calculated with the PB algorithm was 4% higher than the absorbed dose measured with ICs at the deepest measurement point along the spread-out Bragg peak. Results of experiments using melanoma (SKMel) cell line are also presented. The study suggested a pronounced correlation between the relative biological effectiveness (RBE) and LETd, where higher LETd leads to elevated cell death and cell inactivation. Obtained RBE values ranged from 1.4 to 1.8 at the survival level of 10% (RBE10). It is concluded that dosimetric characterization of a phantom before its use for RBE experiments is essential, since a high dosimetric accuracy contributes to reliable RBE data and allows for a clearer differentiation between physical and biological uncertainties.en_US
dc.identifier.citationRadiation and Environmental Biophysics. Vol.58, No.4 (2019), 563-573en_US
dc.identifier.doi10.1007/s00411-019-00813-1en_US
dc.identifier.issn14322099en_US
dc.identifier.issn0301634Xen_US
dc.identifier.other2-s2.0-85072790533en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/50050
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85072790533&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectEnvironmental Scienceen_US
dc.titlePhantom design and dosimetric characterization for multiple simultaneous cell irradiations with active pencil beam scanningen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85072790533&origin=inwarden_US

Files

Collections