Publication: Generation of mature hematopoietic cells from human pluripotent stem cells
Issued Date
2012-06-01
Resource Type
ISSN
18653774
09255710
09255710
Other identifier(s)
2-s2.0-84865043621
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
International Journal of Hematology. Vol.95, No.6 (2012), 617-623
Suggested Citation
Padma Priya Togarrati, Kran Suknuntha Generation of mature hematopoietic cells from human pluripotent stem cells. International Journal of Hematology. Vol.95, No.6 (2012), 617-623. doi:10.1007/s12185-012-1094-x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/14786
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Generation of mature hematopoietic cells from human pluripotent stem cells
Author(s)
Abstract
A number of malignant and non-malignant hematological disorders are associated with the abnormal production of mature blood cells or primitive hematopoietic precursors. Their capacity for continuous self-renewal without loss of pluripotency and the ability to differentiate into adult cell types from all three primitive germ layers make human embryonic stem cells and induced pluripotent stem cells (hiPSCs) attractive complementary cell sources for large-scale production of transfusable mature blood cell components in cell replacement therapies. The generation of patient-specific hematopoietic stem/precursor cells from iPSCs by the regulated manipulation of various factors involved in reprograming to ensure complete pluripotency, and developing innovative differentiation strategies for generating unlimited supply of clinically safe, transplantable, HLA-matched cells from hiPSCs to outnumber the inadequate source of hematopoietic stem cells obtained from cord blood, bone marrow and peripheral blood, would have a major impact on the field of regenerative and personalized medicine leading to translation of these results from bench to bedside. © The Japanese Society of Hematology 2012.