Publication: RV144 vaccine imprinting constrained HIV-1 evolution following breakthrough infection
Issued Date
2021-01-01
Resource Type
ISSN
20571577
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2-s2.0-85116532627
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Virus Evolution. Vol.7, No.2 (2021)
Suggested Citation
Eric Lewitus, Eric Sanders-Buell, Meera Bose, Anne Marie O’Sullivan, Kultida Poltavee, Yifan Li, Hongjun Bai, Thembi Mdluli, Gina Donofrio, Bonnie Slike, Hong Zhao, Kim Wong, Lennie Chen, Shana Miller, Jenica Lee, Bahar Ahani, Steven Lepore, Sevan Muhammad, Rebecca Grande, Ursula Tran, Vincent Dussupt, Letzibeth Mendez-Rivera, Sorachai Nitayaphan, Jaranit Kaewkungwal, Punnee Pitisuttithum, Supachai Rerks-Ngarm, Robert J. O’Connell, Holly Janes, Peter B. Gilbert, Robert Gramzinski, Sandhya Vasan, Merlin L. Robb, Nelson L. Michael, Shelly J. Krebs, Joshua T. Herbeck, Paul T. Edlefsen, James I. Mullins, Jerome H. Kim, Sodsai Tovanabutra, Morgane Rolland RV144 vaccine imprinting constrained HIV-1 evolution following breakthrough infection. Virus Evolution. Vol.7, No.2 (2021). doi:10.1093/ve/veab057 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/77340
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Title
RV144 vaccine imprinting constrained HIV-1 evolution following breakthrough infection
Author(s)
Eric Lewitus
Eric Sanders-Buell
Meera Bose
Anne Marie O’Sullivan
Kultida Poltavee
Yifan Li
Hongjun Bai
Thembi Mdluli
Gina Donofrio
Bonnie Slike
Hong Zhao
Kim Wong
Lennie Chen
Shana Miller
Jenica Lee
Bahar Ahani
Steven Lepore
Sevan Muhammad
Rebecca Grande
Ursula Tran
Vincent Dussupt
Letzibeth Mendez-Rivera
Sorachai Nitayaphan
Jaranit Kaewkungwal
Punnee Pitisuttithum
Supachai Rerks-Ngarm
Robert J. O’Connell
Holly Janes
Peter B. Gilbert
Robert Gramzinski
Sandhya Vasan
Merlin L. Robb
Nelson L. Michael
Shelly J. Krebs
Joshua T. Herbeck
Paul T. Edlefsen
James I. Mullins
Jerome H. Kim
Sodsai Tovanabutra
Morgane Rolland
Eric Sanders-Buell
Meera Bose
Anne Marie O’Sullivan
Kultida Poltavee
Yifan Li
Hongjun Bai
Thembi Mdluli
Gina Donofrio
Bonnie Slike
Hong Zhao
Kim Wong
Lennie Chen
Shana Miller
Jenica Lee
Bahar Ahani
Steven Lepore
Sevan Muhammad
Rebecca Grande
Ursula Tran
Vincent Dussupt
Letzibeth Mendez-Rivera
Sorachai Nitayaphan
Jaranit Kaewkungwal
Punnee Pitisuttithum
Supachai Rerks-Ngarm
Robert J. O’Connell
Holly Janes
Peter B. Gilbert
Robert Gramzinski
Sandhya Vasan
Merlin L. Robb
Nelson L. Michael
Shelly J. Krebs
Joshua T. Herbeck
Paul T. Edlefsen
James I. Mullins
Jerome H. Kim
Sodsai Tovanabutra
Morgane Rolland
Abstract
The scale of the HIV-1 epidemic underscores the need for a vaccine. The multitude of circulating HIV-1 strains together with HIV-1’s high evolvability hints that HIV-1 could adapt to a future vaccine. Here, we wanted to investigate the effect of vaccination on the evolution of the virus post-breakthrough infection. We analyzed 2,635 HIV-1 env sequences sampled up to a year post-diagnosis from 110 vaccine and placebo participants who became infected in the RV144 vaccine efficacy trial. We showed that the Env signature sites that were previously identified to distinguish vaccine and placebo participants were maintained over time. In addition, fewer sites were under diversifying selection in the vaccine group than in the placebo group. These results indicate that HIV-1 would possibly adapt to a vaccine upon its roll-out.