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Expression of androgen receptor and its regulatory molecule lin28 in non-luminal subtype breast cancer

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dc.contributor.authorDoonyapat Sa-Nguanraksaen_US
dc.contributor.authorWanee Pongthongen_US
dc.contributor.authorNorasate Samarnthaien_US
dc.contributor.authorKwanlada Mitpakdien_US
dc.contributor.authorTuenjai Chuangsuwanichen_US
dc.contributor.authorThawornchai Limjindapornen_US
dc.contributor.authorAnchalee Kulpromen_US
dc.contributor.authorPornchai O-Charoenraten_US
dc.contributor.otherFaculty of Medicine, Siriraj Hospital, Mahidol Universityen_US
dc.date.accessioned2020-06-02T04:13:20Z
dc.date.available2020-06-02T04:13:20Z
dc.date.issued2020-01-01en_US
dc.description.abstract© 2020, Spandidos Publications. All rights reserved. Androgen receptor (AR) was associated with favourable outcome in luminal breast cancer. However, the role of AR in non-luminal breast cancer remains inconclusive. The aim of the present study was to evaluate the clinical significance of t he AR and its regulator y pat hway in non-luminal subtypes of breast cancer. In total, 284 breast cancer patients were recruited from January 2007 to January 2016. Tissue microarrays were constructed from archival paraffin blocks and assessed for AR and its regulatory molecule, Lin28, by immunohistochemistry. The association between AR and Lin28 expression and clinicopathological parameters was analyzed. Results showed that AR and Lin28 were co-expressed. No association between these proteins and clinicopathological parameters, and survival outcome was found. However, a higher proportion of the patients with AR and Lin28 expression were observed in HER2 subtype. In conclusion, Lin28 may be a novel marker for prognosis and targeted for treatment in HER2 subtype breast cancer.en_US
dc.identifier.citationMolecular and Clinical Oncology. Vol.12, No.6 (2020), 511-518en_US
dc.identifier.doi10.3892/mco.2020.2029en_US
dc.identifier.issn20499469en_US
dc.identifier.issn20499450en_US
dc.identifier.other2-s2.0-85085348674en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/56132
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85085348674&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectMedicineen_US
dc.titleExpression of androgen receptor and its regulatory molecule lin28 in non-luminal subtype breast canceren_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85085348674&origin=inwarden_US

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