Publication: Do we need perioperative pharmacogenetic testing?
Issued Date
2018-09-01
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ISSN
01252208
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2-s2.0-85064225361
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.101, No.9 (2018), S159-S166
Suggested Citation
Sirirat Rattana-Arpa, Patcharee Sriswasdi Do we need perioperative pharmacogenetic testing?. Journal of the Medical Association of Thailand. Vol.101, No.9 (2018), S159-S166. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/46340
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Title
Do we need perioperative pharmacogenetic testing?
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Abstract
© 2018, Medical Association of Thailand. All rights reserved. Multiple drugs with various mechanisms of actions are used simultaneously during anesthetic practice. Even if the same dose of drug is administered, diverse individual responses usually occur. These different responses might relate to their pharmacogenetics variation. The pharmacogenetics research network has established a pharmacogenetics knowledge base in order to collect, encode, and disseminate knowledge about the impact of human genetic variations on drug response. For perioperative period, opioids are the common drugs used with various individual responses. This review shows the pharmacogenetic aspects of four common opioids: morphine, fentanyl, codeine and oxycodone, and their future trends for perioperative pharmacogenetic testing.