Publication:
FAILURE OF CHLOROQUINE-ERYTHROMYCIN AND CHLOROQUINE-TETRACYCLINE COMBINATIONS IN TREATMENT OF CHLOROQUINE-RESISTANT FALCIPARUM MALARIA IN EASTERN THAILAND

Issued Date

1984-02-11

Resource Type

Article

ISSN

01406736

DOI

10.1016/S0140-6736(84)90357-X

Other identifier(s)

2-s2.0-0021333307

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

The Lancet. Vol.323, No.8372 (1984), 300-302

Suggested Citation

Rodney E. Phillips, Juntra Karbwang, Nicholas J. White, Sornchai Looareesuwan, David A. Warrell, Prakit Kasemsarn, David C. Warhurst FAILURE OF CHLOROQUINE-ERYTHROMYCIN AND CHLOROQUINE-TETRACYCLINE COMBINATIONS IN TREATMENT OF CHLOROQUINE-RESISTANT FALCIPARUM MALARIA IN EASTERN THAILAND. The Lancet. Vol.323, No.8372 (1984), 300-302. doi:10.1016/S0140-6736(84)90357-X Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/30665

Research Projects

Organizational Units

Authors

Journal Issue

Thesis

Title

FAILURE OF CHLOROQUINE-ERYTHROMYCIN AND CHLOROQUINE-TETRACYCLINE COMBINATIONS IN TREATMENT OF CHLOROQUINE-RESISTANT FALCIPARUM MALARIA IN EASTERN THAILAND

Author(s)

Rodney E. Phillips
 Juntra Karbwang
 Nicholas J. White
 Sornchai Looareesuwan
 David A. Warrell
 Prakit Kasemsarn
 David C. Warhurst

Other Contributor(s)

Mahidol University
 Oxford University Press UK

Abstract

In Eastern Thailand the increasing resistance of Plasmodium falciparum to all available antimalarial drugs prompted a reassessment of chloroquine in combination with either erythromycin or tetracycline. Both combinations had produced encouraging results in vitro, in experimental animal models, or in preliminary clinical trials. In patients with uncomplicated falciparum malaria presenting with moderate parasitaemia the trial of chloroquine and tetracycline was abandoned after RIII resistance with clinical deterioration was encountered in 2 out of the first 5 patients studied. Of 16 patients treated with chloroquine + erythromycin, 11 showed resistance (RI-RIII). These regimens appear ineffective and potentially dangerous in Eastern Thailand. © 1984.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/30665

Collections

Scopus 1969-1990