Publication: Possible involvement of glucocorticoids in mycotoxin-induced neuroinflammation
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2015
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eng
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1906-2257
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Mahidol University
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Faculty of Veterinary Science Mahidol University
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Journal of Applied Animal Science. Vol.8, No.1 (2015), 17-28
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Boonrat Chantong, Punnee Nusuetrong Possible involvement of glucocorticoids in mycotoxin-induced neuroinflammation. Journal of Applied Animal Science. Vol.8, No.1 (2015), 17-28. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/13343
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Possible involvement of glucocorticoids in mycotoxin-induced neuroinflammation
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การมีส่วนร่วมของสารกลุ่มกลูโคคอร์ติคอยด์ต่อกระบวนการอักเสบของระบบประสาทที่เกิดจากการชักนำของสารพิษจากเชื้อรา
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The mycotoxins are commonly encountered in human cereal foods and animal feed throughout the
world as a result of infestation of grains in the field and in storage by the fungi including genus Aspergillus,
Penicillum and Fusarium. Modulation of the inflammatory responses in the central nervous system (CNS)
appears particularly critical role of some relevance mycotoxins such as T-2 toxin, fumonisin B1 and ochratoxin A.
Specifically, mentioned mycotoxins disturbed mitogen-activated protein kinases (MAPKs) as well as nuclear
factor kappa-light-chain-enhancer of activated B cells (NF-κB) which mediate robust induction of proinflammatory
gene expression in both in vitro and in vivo. In CNS, glucocorticoids are powerful endogenous
and therapeutic modulators of inflammation though both MAPKs and NF-κB signaling. In addition, toxicity of
mycotoxins also was altered with glucocorticoid. Taken together, glucocorticoids may possibly involve in the
action of mycotoxins on neuroinflammatory responses. Therefore, factors disturbing glucocorticoid regulation
in CNS such as stress, infection, and xenobiotics may enhance response to mycotoxin toxicity. It is anticipated
that these investigations will be applicable to identify the therapeutic intervention or prevention.