Publication: Viral load of the highly pathogenic avian influenza H5N1 virus in infected human tissues
Issued Date
2011-08-01
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ISSN
10969071
01466615
01466615
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2-s2.0-79959194659
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Medical Virology. Vol.83, No.8 (2011), 1418-1423
Suggested Citation
Naraporn Sirinonthanawech, Mongkol Uiprasertkul, Ornpreya Suptawiwat, Prasert Auewarakul Viral load of the highly pathogenic avian influenza H5N1 virus in infected human tissues. Journal of Medical Virology. Vol.83, No.8 (2011), 1418-1423. doi:10.1002/jmv.22146 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/12012
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Title
Viral load of the highly pathogenic avian influenza H5N1 virus in infected human tissues
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Abstract
The highly pathogenic avian influenza A (H5N1) virus is a virulent virus that causes an acute febrile respiratory disease with high mortality in humans. To gain a better insight of H5N1 viral distributions in infected human tissues, the levels of viral RNA were determined in the autopsy tissues from two patients who were infected with H5N1 virus by using real-time reverse transcription-polymerase chain reaction. In one patient who died on day 6 of the illness, the viral load in the lung was extremely high, whereas the levels of viral RNA in the other organs were more than 6 log lower. In the other patient who died on day 17 of the illness, the viral load was similar in the lung and other organs, and was comparable to the viral load in the extra-pulmonary tissues of the first patient. These results suggested that while the H5N1 virus can cause disseminated infection in humans, the lung is still the major site of viral replication, and viral replication in the lung in the later stages may decrease as a result of the depletion of the available target cells. In addition, the mRNA levels of the tumor necrosis factor-α (TNF-α) were found to be associated with the viral titers. © 2011 Wiley-Liss, Inc..