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The draft genome sequence of Actinokineospora bangkokensis 44EHW<sup>T</sup>reveals the biosynthetic pathway of the antifungal thailandin compounds with unusual butylmalonyl-CoA extender units

Issued Date

2016-11-01

Resource Type

Article

ISSN

14203049

DOI

10.3390/molecules21111607

Other identifier(s)

2-s2.0-84997610979

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Molecules. Vol.21, No.11 (2016)

Suggested Citation

Anja Greule, Bungonsiri Intra, Stephan Flemming, Marcel G.E. Rommel, Watanalai Panbangred, Andreas Bechthold The draft genome sequence of Actinokineospora bangkokensis 44EHW<sup>T</sup>reveals the biosynthetic pathway of the antifungal thailandin compounds with unusual butylmalonyl-CoA extender units. Molecules. Vol.21, No.11 (2016). doi:10.3390/molecules21111607 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/43324

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Title

The draft genome sequence of Actinokineospora bangkokensis 44EHW<sup>T</sup>reveals the biosynthetic pathway of the antifungal thailandin compounds with unusual butylmalonyl-CoA extender units

Author(s)

Anja Greule
 Bungonsiri Intra
 Stephan Flemming
 Marcel G.E. Rommel
 Watanalai Panbangred
 Andreas Bechthold

Other Contributor(s)

Universität Freiburg im Breisgau
 Mahidol University

Abstract

© 2016 by the authors; licensee MDPI. We report the draft genome sequence of Actinokineospora bangkokensis 44EHWT, the producer of the antifungal polyene compounds, thailandins A and B. The sequence contains 7.45 Mb, 74.1% GC content and 35 putative gene clusters for the biosynthesis of secondary metabolites. There are three gene clusters encoding large polyketide synthases of type I. Annotation of the ORF functions and targeted gene disruption enabled us to identify the cluster for thailandin biosynthesis. We propose a plausible biosynthetic pathway for thailandin, where the unusual butylmalonyl-CoA extender unit is incorporated and results in an untypical side chain.

Keyword(s)

Chemistry
 Medicine

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https://repository.li.mahidol.ac.th/handle/20.500.14594/43324

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Scopus 2016-2017