Publication: The inhibitory potential of thai mango seed kernel extract against methicillin-resistant staphylococcus aureus
Issued Date
2011-08-01
Resource Type
ISSN
14203049
Other identifier(s)
2-s2.0-80052215672
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Molecules. Vol.16, No.8 (2011), 6255-6270
Suggested Citation
Pimsumon Jiamboonsri, Pimolpan Pithayanukul, Rapepol Bavovada, Mullika T. Chomnawang The inhibitory potential of thai mango seed kernel extract against methicillin-resistant staphylococcus aureus. Molecules. Vol.16, No.8 (2011), 6255-6270. doi:10.3390/molecules16086255 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/11704
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
The inhibitory potential of thai mango seed kernel extract against methicillin-resistant staphylococcus aureus
Other Contributor(s)
Abstract
Plant extracts are a valuable source of novel antibacterial compounds to combat pathogenic isolates of methicillin-resistant Staphylococcus aureus (MRSA), a global nosocomial infection. In this study, the alcoholic extract from Thai mango (Mangifera indica L. cv. 'Fahlun') seed kernel extract (MSKE) and its phenolic principles (gallic acid, methyl gallate and pentagalloylglucopyranose) demonstrated potent in vitro antibacterial activity against Staphylococcus aureus and 19 clinical MRSA isolates in studies of disc diffusion, broth microdilution and time-kill assays. Electron microscopy studies using scanning electron microscopy and transmission electron microscopy revealed impaired cell division and ultra-structural changes in bacterial cell morphology, including the thickening of cell walls, of microorganisms treated with MSKE; these damaging effects were increased with increasing concentrations of MSKE. MSKE and its phenolic principles enhanced and intensified the antibacterial activity of penicillin G against 19 clinical MRSA isolates by lowering the minimum inhibitory concentration by at least 5-fold. The major phenolic principle, pentagalloylglucopyranose, was demonstrated to be the major contributor to the antibacterial activity of MSKE. These results suggest that MSKE may potentially be useful as an alternative therapeutic agent or an adjunctive therapy along with penicillin G in the treatment of MRSA infections.