Publication: Halogenated benzoate derivatives of altholactone with improved anti-fungal activity
Issued Date
2016-01-01
Resource Type
ISSN
14772213
10286020
10286020
Other identifier(s)
2-s2.0-84954289948
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Asian Natural Products Research. Vol.18, No.5 (2016), 462-474
Suggested Citation
Jirayut Euanorasetr, Mayura Junhom, Srisurang Tantimavanich, Onanong Vorasin, Bamroong Munyoo, Patoomratana Tuchinda, Watanalai Panbangred Halogenated benzoate derivatives of altholactone with improved anti-fungal activity. Journal of Asian Natural Products Research. Vol.18, No.5 (2016), 462-474. doi:10.1080/10286020.2015.1133611 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/43193
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Halogenated benzoate derivatives of altholactone with improved anti-fungal activity
Other Contributor(s)
Abstract
© 2016 Informa UK Limited, trading as Taylor & Francis Group. Abstract: Altholactone exhibited the anti-fungal activity with a high MIC value of 128 μg ml−1against Cryptococcus neoformans and Saccharomyces cerevisiae. Fifteen ester derivatives of altholactone 1–15 were modified by esterification and their structures were confirmed by spectroscopic methods. Most of the ester derivatives exhibited stronger anti-fungal activities than that of the precursor altholactone. 3-Bromo- and 2,4-dichlorobenzoates (7 and 15) exhibited the lowest minimal inhibitory concentration (MIC) values against C. neoformans at 16 μg ml−1,while the 4-bromo-, 4-iodo-, and 1-bromo-3-chlorobenzoates (11–13) displayed potent activity against S. cerevisiae with MIC values of 1 μg ml−1. In conclusion, this analysis indicates that the anti-fungal activity of altholactone is enhanced by addition of halogenated benzoyl group to the 3-OH group.