Publication: Favipiravir therapy for patients with covid-19 pneumonia: An observational study
11
Issued Date
2021-02-04
Resource Type
ISSN
26975718
01251562
01251562
Other identifier(s)
2-s2.0-85119835401
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.52, No.1 (2021), 161-174
Suggested Citation
Supawadee Suppadungsuk, Thananya Wongsinin, Sirawat Srichatrapimuk, Suppachok Kirdlarp, Kulapong Jayanama, Kanin Thammavaranucupt, Dhanesh Pitidhammabhorn, Sithakom Phusanti, Nithita Nanthatanti, Somnuek Sungkanuparph Favipiravir therapy for patients with covid-19 pneumonia: An observational study. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.52, No.1 (2021), 161-174. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/78454
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Favipiravir therapy for patients with covid-19 pneumonia: An observational study
Other Contributor(s)
Abstract
Pneumonia in patients with COVID-19 is sometimes severe and life-threatening, and currently there is no specific effective drug approved for COVID-19 treatment. Favipiravir is a pyrazine analog inhibiting RNA virus RNA dependent RNA polymerase with antiviral activity against SARS-CoV-2. An observational study was conducted in confirmed COVID-19 pneumonia patients admitted to a university hospital in Thailand on effectiveness and safety of favipiravir prescribed on a compassionate-use basis. Among COVID-19 patients with pneumonia (n = 37), 54 and 46% had severe and non-severe pneumonia, respectively. Mean ± SD age was 48 ± 3 years, 62% were male and diabetes mellitus and hypertension were the most common comorbidities. Median period from initiation of favipiravir treatment to clinical improvement of patients with severe and non-severe pneumonia was 17 days (95% confidence interval (CI): 9-25) and 9 days (95% CI: 7-11) respectively. Ninety-five percent of patients completely recovered and were discharged within 39 days following admittance; unfortunately, the remaining patients succumbed to severe acute respiratory distress syndrome and multi-organ failure. In conclusion, favipiravir holds promise as a potential drug for treatment of COVID-19 pneumonia, but a larger randomized trial is warranted to confirm its efficacy.