Effects of antibody to Vibrio cholerae El Tor hemolysin on pathological changes of the intestines in cholera

Abstract

Pathological abnormalities of the infant mouse small intestine were evident after V.cholerae El Tor, Ogawa, infection. These were revealed by an enteritis manifested by mononuclear cells containing inflammatory exudate, intervillous blood capillar congestion, marked increase in goblet cells, desquamation of epithelium and diapedesis of cells. Mice received V.chloreae pretreated with a high concentration of antihemolysin, though developing diarrhea, showed a marked decrease in pathological severity. The less amount of the antibodies the more pathological changes were found.