Publication: Peptidomics and proteogenomics: background, challenges and future needs
Issued Date
2021-01-01
Resource Type
ISSN
17448387
14789450
14789450
Other identifier(s)
2-s2.0-85115654380
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Mahidol University
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SCOPUS
Bibliographic Citation
Expert Review of Proteomics. Vol.18, No.8 (2021), 643-659
Suggested Citation
Rui Vitorino, Manisha Choudhury, Sofia Guedes, Rita Ferreira, Visith Thongboonkerd, Lakshya Sharma, Francisco Amado, Sanjeeva Srivastava Peptidomics and proteogenomics: background, challenges and future needs. Expert Review of Proteomics. Vol.18, No.8 (2021), 643-659. doi:10.1080/14789450.2021.1980388 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/76332
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Title
Peptidomics and proteogenomics: background, challenges and future needs
Abstract
Introduction: With available genomic data and related information, it is becoming possible to better highlight mutations or genomic alterations associated with a particular disease or disorder. The advent of high-throughput sequencing technologies has greatly advanced diagnostics, prognostics, and drug development. Areas covered: Peptidomics and proteogenomics are the two post-genomic technologies that enable the simultaneous study of peptides and proteins/transcripts/genes. Both technologies add a remarkably large amount of data to the pool of information on various peptides associated with gene mutations or genome remodeling. Literature search was performed in the PubMed database and is up to date. Expert Opinion: This article lists various techniques used for peptidomic and proteogenomic analyses. It also explains various bioinformatics workflows developed to understand differentially expressed peptides/proteins and their role in disease pathogenesis. Their role in deciphering disease pathways, cancer research, and biomarker discovery using biofluids is highlighted. Finally, the challenges and future requirements to overcome the current limitations for their effective clinical use are also discussed.