Publication: Hepatitis B immunization in high risk neonates born from HBsAg and HBeAg positive mothers: comparison of standard and low dose regimens
Issued Date
1988-12-01
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0125877X
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2-s2.0-0024273502
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Mahidol University
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SCOPUS
Bibliographic Citation
Asian Pacific Journal of Allergy and Immunology. Vol.6, No.2 (1988), 107-110
Suggested Citation
D. Pongpipat, V. Suvatte, A. Assateerawatts Hepatitis B immunization in high risk neonates born from HBsAg and HBeAg positive mothers: comparison of standard and low dose regimens. Asian Pacific Journal of Allergy and Immunology. Vol.6, No.2 (1988), 107-110. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/15552
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Title
Hepatitis B immunization in high risk neonates born from HBsAg and HBeAg positive mothers: comparison of standard and low dose regimens
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Abstract
A reduced dose of plasma derived hepatitis B vaccine (Hevac B®) was tested for efficacy in the prevention of perinatal hepatitis B virus (HBV) transmission in high risk neonates born from e-antigen positive HBsAg carrier mothers. Forty newborn infants born of these mothers were given hepatitis B immune globulin (HBIG) 100 IU intramuscularly immediately after birth, combined with either standard or reduced doses of HBV vaccine. The infants were divided into two groups of 20 infants each. The standard dose of HBV vaccine (5 μg) was given to group I, while infants in group II received reduced dose (2 μg) at birth and at 1, 2 and 12 months of age. There was no statistically significant difference in the efficacy and antibody response of these two combined prophylaxis regimens. The protective efficacy rate of HBV vaccine was found to be 94.0 and 93.2 percent in group I and group II, respectively. At twelve months of age, the anti-HBs sero-conversion rates were 80.0 percent in group I and 86.7 percent in group II, with geometric mean titres of 84.57 mlU/ml and 78.56 mlU/ml, in group I and group II, respectively. One month after a booster at one year of age, anti-HBs could be detected in 86.7 percent of the infants in both groups. The geometric mean titres were 429.04 and 664.81 mlU/ml, in group I and group II, respectively. Anti-PreS2 antibody was detected in high titre as early as 4 months after the first dose of HBV vaccine, with a geometric mean titre of 116.30 mlU/ml and 107.97 mlU/ml, in group I and group II, respectively. It is concluded that a reduced dose (2 μg) of plasma derived hepatitis B vaccine (Hevac ®) could be used as effectively as the standard dose (5 μg) in the prevention of perinatal HBV transmission in high risk neonates born from e-antigen positive HBsAg carrier mothers.