Publication:
Clozapine-induced agranulocytosis and leukopenia: Incidence, associated factors, and rate of hematologic adverse-effects monitoring in psychiatric out-patient services in Thailand

Issued Date

2019-03-01

Resource Type

Article

ISSN

18762026
18762018

DOI

10.1016/j.ajp.2019.03.002

Other identifier(s)

2-s2.0-85062495210

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Asian Journal of Psychiatry. Vol.41, (2019), 13-16

Suggested Citation

Noppawan Tunsirimas, Pornjira Pariwatcharakul, Somrak Choovanichvong, Woraphat Ratta-apha Clozapine-induced agranulocytosis and leukopenia: Incidence, associated factors, and rate of hematologic adverse-effects monitoring in psychiatric out-patient services in Thailand. Asian Journal of Psychiatry. Vol.41, (2019), 13-16. doi:10.1016/j.ajp.2019.03.002 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/51830

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Title

Clozapine-induced agranulocytosis and leukopenia: Incidence, associated factors, and rate of hematologic adverse-effects monitoring in psychiatric out-patient services in Thailand

Author(s)

Noppawan Tunsirimas
 Pornjira Pariwatcharakul
 Somrak Choovanichvong
 Woraphat Ratta-apha

Other Contributor(s)

Srithanya Hospital
 Faculty of Medicine, Siriraj Hospital, Mahidol University
 Nakorn Ratchasima Rajanagarindra Psychiatric Hospital

Abstract

© 2019 Elsevier B.V. The present study aimed to investigate the incidence of agranulocytosis and leukopenia and its associated factors in Thai schizophrenia patients treated with clozapine and the rate of hematologic adverse events monitored in clinical practice. Data were collected from the medical records of 641 outpatients at two hospitals. The results showed no cases of agranulocytosis and 20 cases of leukopenia (3.1%), 85% of which were observed after 1 year of prescription. The associated factors were female (p = 0.019) and duration of clozapine prescription (p = 0.026). According to the guideline for safety monitoring, 23.6% of cases had neutrophils count monitoring.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/51830

Collections

Scopus 2019