Publication: Genetic Variations and Frequencies of the Two Functional Single Nucleotide Polymorphisms of SLCO1B1 in the Thai Population
Issued Date
2020-06-05
Resource Type
ISSN
16639812
Other identifier(s)
2-s2.0-85087028894
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Frontiers in Pharmacology. Vol.11, (2020)
Suggested Citation
Chalitpon Na nakorn, Jariya Waisayarat, Charungthai Dejthevaporn, Pornpen Srisawasdi, Sansanee Wongwaisayawan, Chonlaphat Sukasem Genetic Variations and Frequencies of the Two Functional Single Nucleotide Polymorphisms of SLCO1B1 in the Thai Population. Frontiers in Pharmacology. Vol.11, (2020). doi:10.3389/fphar.2020.00728 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/58131
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Genetic Variations and Frequencies of the Two Functional Single Nucleotide Polymorphisms of SLCO1B1 in the Thai Population
Abstract
© Copyright © 2020 Na nakorn, Waisayarat, Dejthevaporn, Srisawasdi, Wongwaisayawan and Sukasem. Aim: To investigate the variations and the frequencies of the SLCO1B1 gene in the Thai population. Methods: Collected samples were categorized into five regions of Thailand. DNA samples were genotyped for two variants, c.388A>G and c.521T>C of the SLCO1B1, using TaqMan® real-time PCR. Results: The minor allele frequencies (MAFs) of two single nucleotide polymorphisms (SNPs) were not significantly different among the five regions. The most frequent haplotype was SLCO1B1*1b (frequency: 0.654), followed by *1a (frequency: 0.217), *15 (frequency: 0.128), and *5 (frequency: 0.001). We observed a similar frequency of OATP1B1 transporter phenotypes compared to other populations. 75.85% of the Thai subjects showed normal OATP1B1 activity, 22.5% showed intermediate OATP1B1 activity, and 1.58% showed low OATP1B1 activity. Conclusion: This study reported the frequencies of the SLCO1B1 variants and the subsequent OATP1B1 activity in a large cohort of Thais that can provide important information for the guidance of personalized drug therapy.