Publication: Iron overload in the Asian community
Issued Date
2009-11-18
Resource Type
ISSN
15280020
00064971
00064971
Other identifier(s)
2-s2.0-67651018727
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Mahidol University
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SCOPUS
Bibliographic Citation
Blood. Vol.114, No.1 (2009), 20-25
Suggested Citation
Yu Lok Chun, Alison T. Merryweather-Clarke, Vip Viprakasit, Yingyong Chinthammitr, Somdet Srichairatanakool, Chanin Limwongse, David Oleesky, Anthony J. Robins, John Hudson, Phyu Wai, Anuja Premawardhena, H. Janaka De Silva, Anuradha Dassanayake, Carole McKeown, Maurice Jackson, Rousseau Gama, Nasaim Khan, William Newman, Gurvinder Banait, Andrew Chilton, Isaac Wilson-Morkeh, David J. Weatherall, Kathryn J.H. Robson Iron overload in the Asian community. Blood. Vol.114, No.1 (2009), 20-25. doi:10.1182/blood-2009-01-199109 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/27116
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Title
Iron overload in the Asian community
Author(s)
Yu Lok Chun
Alison T. Merryweather-Clarke
Vip Viprakasit
Yingyong Chinthammitr
Somdet Srichairatanakool
Chanin Limwongse
David Oleesky
Anthony J. Robins
John Hudson
Phyu Wai
Anuja Premawardhena
H. Janaka De Silva
Anuradha Dassanayake
Carole McKeown
Maurice Jackson
Rousseau Gama
Nasaim Khan
William Newman
Gurvinder Banait
Andrew Chilton
Isaac Wilson-Morkeh
David J. Weatherall
Kathryn J.H. Robson
Alison T. Merryweather-Clarke
Vip Viprakasit
Yingyong Chinthammitr
Somdet Srichairatanakool
Chanin Limwongse
David Oleesky
Anthony J. Robins
John Hudson
Phyu Wai
Anuja Premawardhena
H. Janaka De Silva
Anuradha Dassanayake
Carole McKeown
Maurice Jackson
Rousseau Gama
Nasaim Khan
William Newman
Gurvinder Banait
Andrew Chilton
Isaac Wilson-Morkeh
David J. Weatherall
Kathryn J.H. Robson
Other Contributor(s)
Abstract
Hereditary hemochromatosis is an iron overload disorder that can lead to the impairment of multiple organs and is caused by mutations in one or more different genes. Type 1 hemochromatosis is the most common form of the disease and results from mutations in the HFE gene. Juvenile hemochromatosis (JH) is the most severe form, usually caused by mutations in hemojuvelin (HJV) or hepcidin (HAMP). The autosomal dominant form of the disease, type 4, is due to mutations in the SLC40A1 gene, which encodes for ferroportin (FPN). Hereditary hemochromatosis is commonly found in populations of European origin. By contrast, hemochromatosis in Asia is rare and less well understood and can be masked by the presence of iron deficiency and secondary iron overload from thalassemia. Here, weprovide a comprehensive report of hemochromatosis in a group of patients of Asian origin. We have identified novel mutations in HJV, HAMP, and SLC40A1 in countries not normally associated with hereditary hemochromatosis (Pakistan, Bangladesh, Sri Lanka, and Thailand). Our family studies show a high degree of consanguinity, highlighting the increased risk of iron overload in many countries of the developing world and in countries in which there are large immigrant populations from these regions. © 2009 by The American Society of Hematology.