Publication:
Genomic epidemiology of artemisinin resistant malaria

Issued Date

2016-03-04

Resource Type

Article

ISSN

2050084X

DOI

10.7554/eLife.08714

Other identifier(s)

2-s2.0-84961932806

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

eLife. Vol.5, No.MARCH2016 (2016)

Suggested Citation

Roberto Amato, Olivo Miotto, Charles J. Woodrow, Jacob Almagro-Garcia, Ipsita Sinha, Susana Campino, Daniel Mead, Eleanor Drury, Mihir Kekre, Mandy Sanders, Alfred Amambua-Ngwa, Chanaki Amaratunga, Lucas Amenga-Etego, Voahangy Andrianaranjaka, Tobias Apinjoh, Elizabeth Ashley, Sarah Auburn, Gordon A. Awandare, Vito Baraka, Alyssa Barry, Maciej F. Boni, Steffen Borrmann, Teun Bousema, Oralee Branch, Peter C. Bull, Kesinee Chotivanich, David J. Conway, Alister Craig, Nicholas P. Day, Abdoulaye Djimdé, Christiane Dolecek, Arjen M. Dondorp, Chris Drakeley, Patrick Duffy, Diego F. Echeverry, Thomas G. Egwang, Rick M. Fairhurst, Abul Faiz, Caterina I. Fanello, Tran Tinh Hien, Abraham Hodgson, Mallika Imwong, Deus Ishengoma, Pharath Lim, Chanthap Lon, Jutta Marfurt, Kevin Marsh, Mayfong Mayxay, Pascal Michon, Victor Mobegi, Olugbenga A. Mokuolu, Jacqui Montgomery, Ivo Mueller, Myat Phone Kyaw, Paul N. Newton, Francois Nosten, Rintis Noviyanti, Alexis Nzila, Harold Ocholla, Abraham Oduro, Marie Onyamboko, Jean Bosco Ouedraogo, Aung Pyae P. Phyo, Christopher Plowe, Ric N. Price, Sasithon Pukrittayakamee, Milijaona Randrianarivelojosia, Pascal Ringwald, Lastenia Ruiz, David Saunders, Alex Shayo, Peter Siba, Shannon Takala-Harrison, Thuy Nhien N. Thanh, Vandana Thathy, Federica Verra, Jason Wendler Genomic epidemiology of artemisinin resistant malaria. eLife. Vol.5, No.MARCH2016 (2016). doi:10.7554/eLife.08714 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/43071

Research Projects

Organizational Units

Authors

Journal Issue

Thesis

Title

Genomic epidemiology of artemisinin resistant malaria

Author(s)

Roberto Amato
 Olivo Miotto
 Charles J. Woodrow
 Jacob Almagro-Garcia
 Ipsita Sinha
 Susana Campino
 Daniel Mead
 Eleanor Drury
 Mihir Kekre
 Mandy Sanders
 Alfred Amambua-Ngwa
 Chanaki Amaratunga
 Lucas Amenga-Etego
 Voahangy Andrianaranjaka
 Tobias Apinjoh
 Elizabeth Ashley
 Sarah Auburn
 Gordon A. Awandare
 Vito Baraka
 Alyssa Barry
 Maciej F. Boni
 Steffen Borrmann
 Teun Bousema
 Oralee Branch
 Peter C. Bull
 Kesinee Chotivanich
 David J. Conway
 Alister Craig
 Nicholas P. Day
 Abdoulaye Djimdé
 Christiane Dolecek
 Arjen M. Dondorp
 Chris Drakeley
 Patrick Duffy
 Diego F. Echeverry
 Thomas G. Egwang
 Rick M. Fairhurst
 Abul Faiz
 Caterina I. Fanello
 Tran Tinh Hien
 Abraham Hodgson
 Mallika Imwong
 Deus Ishengoma
 Pharath Lim
 Chanthap Lon
 Jutta Marfurt
 Kevin Marsh
 Mayfong Mayxay
 Pascal Michon
 Victor Mobegi
 Olugbenga A. Mokuolu
 Jacqui Montgomery
 Ivo Mueller
 Myat Phone Kyaw
 Paul N. Newton
 Francois Nosten
 Rintis Noviyanti
 Alexis Nzila
 Harold Ocholla
 Abraham Oduro
 Marie Onyamboko
 Jean Bosco Ouedraogo
 Aung Pyae P. Phyo
 Christopher Plowe
 Ric N. Price
 Sasithon Pukrittayakamee
 Milijaona Randrianarivelojosia
 Pascal Ringwald
 Lastenia Ruiz
 David Saunders
 Alex Shayo
 Peter Siba
 Shannon Takala-Harrison
 Thuy Nhien N. Thanh
 Vandana Thathy
 Federica Verra
 Jason Wendler

Other Contributor(s)

Wellcome Trust Sanger Institute
 Wellcome Trust Centre for Human Genetics
 Mahidol University
 Nuffield Department of Clinical Medicine
 Medical Research Council Laboratories Gambia
 National Institute of Allergy and Infectious Diseases
 Navrongo Health Research Center
 Institut Pasteur de Madagascar
 University of Buea
 Menzies School of Health Research
 University of Ghana
 National Institute for Medical Research Tanga
 Universiteit Antwerpen
 Walter and Eliza Hall Institute of Medical Research
 University of Melbourne
 University of Oxford
 Kenya Medical Research Institute
 Universität Tübingen
 London School of Hygiene & Tropical Medicine
 NYU School of Medicine
 Liverpool School of Tropical Medicine
 University of Bamako
 Oxford University Clinical Research Unit
 Purdue University
 Centro Internacional de Entrenamiento e Investigaciones Medicas
 Med Biotech Laboratories Uganda
 Malaria Research Group and Dev Care Foundation
 National Centre for Parasitology, Entomology and Malaria Control
 Armed Forces Research Institute of Medical Sciences, Thailand
 Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU)
 University of Health Sciences
 Divine Word University
 University of Ilorin
 Pennsylvania State University
 Ministry of Health
 Shoklo Malaria Research Unit
 Eijkman Institute for Molecular Biology
 King Fahd University of Petroleum and Minerals
 Malawi-Liverpool-Wellcome Trust
 Universite de Kinshasa
 Institut de Recherche en Sciences de la Santé
 University of Maryland School of Medicine
 Organisation Mondiale de la Sante
 Universidad Nacional de la Amazonia Peruana, Iquitos
 University of Dodoma
 Papua New Guinea Institute of Medical Research

Abstract

© 2016, eLife Sciences Publications Ltd. All rights reserved. The current epidemic of artemisinin resistant Plasmodium falciparum in Southeast Asia is the result of a soft selective sweep involving at least 20 independent kelch13 mutations. In a large global survey, we find that kelch13 mutations which cause resistance in Southeast Asia are present at low frequency in Africa. We show that African kelch13 mutations have originated locally, and that kelch13 shows a normal variation pattern relative to other genes in Africa, whereas in Southeast Asia there is a great excess of non-synonymous mutations, many of which cause radical amino-acid changes. Thus, kelch13 is not currently undergoing strong selection in Africa, despite a deep reservoir of variations that could potentially allow resistance to emerge rapidly. The practical implications are that public health surveillance for artemisinin resistance should not rely on kelch13 data alone, and interventions to prevent resistance must account for local evolutionary conditions, shown by genomic epidemiology to differ greatly between geographical regions.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Immunology and Microbiology

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/43071

Collections

Scopus 2016-2017