Publication: Pharmacokinetics of artemether after oral administration to healthy Thai males and patients with acute, uncomplicated falciparum malaria.
Issued Date
1994-01-01
Resource Type
ISSN
13652125
03065251
03065251
Other identifier(s)
2-s2.0-0028357240
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Mahidol University
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SCOPUS
Bibliographic Citation
British Journal of Clinical Pharmacology. Vol.37, No.3 (1994), 249-253
Suggested Citation
K. Na Bangchang, J. Karbwang, CG Thomas, A. Thanavibul, K. Sukontason, SA Ward, G. Edwards Pharmacokinetics of artemether after oral administration to healthy Thai males and patients with acute, uncomplicated falciparum malaria.. British Journal of Clinical Pharmacology. Vol.37, No.3 (1994), 249-253. doi:10.1111/j.1365-2125.1994.tb04271.x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/9752
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Title
Pharmacokinetics of artemether after oral administration to healthy Thai males and patients with acute, uncomplicated falciparum malaria.
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Abstract
1. The pharmacokinetics of artemether were investigated (a) in six healthy male Thai volunteers after single 200 mg oral doses and (b) in eight male Thai patients with acute uncomplicated falciparum malaria after an initial 200 mg oral dose followed by 100 mg at 12 h then 100 mg daily for 4 days. 2. In the healthy subjects, median (range) maximum plasma concentrations of artemether of 118 (112‐127) ng ml‐1 were reached at 3 (1‐10) h. Thereafter, drug concentrations declined monoexponentially with a median (range) t1/2.z of 3.1 (1.0‐9.6) h. The median (range) AUC and MRT values were 1.10 (0.33‐4.44) micrograms ml‐1 h and 8.3 (3.5‐20.8) h. The median Cmax value of dihydroartemisinin, an active metabolite, was 379 (162‐702) mg ml‐1 at 6 (2‐12) h. Its median AUC value was 6.6 (0.83‐38.7) micrograms ml‐1 h; the apparent t1/2.z was 10.6 (4.7‐19.2) h and the median MRT value was 16.0 (5.0‐41.0) h. 3. In the patients, a higher Cmax value of parent drug than those observed in healthy subjects (median and range of 231 (116‐411) ng ml‐ 1), was reached at 3 (1‐3) h after the first dose. Steady state was reached after the third dose (24 h) and concentrations fluctuated over the range of 36‐60 ng ml‐1. The respective median (range) values of AUC and t1/2.z were 5.8 (3.76‐12.9) micrograms ml‐1 h and 4.2 (2.5‐5.3) h.(ABSTRACT TRUNCATED AT 250 WORDS) 1994 The British Pharmacological Society