Publication: The effectiveness of 3, 5 or 7 days of albendazole for the treatment of Trichuris trichiura infection
Issued Date
2003-12-01
Resource Type
ISSN
00034983
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2-s2.0-0347361459
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Mahidol University
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SCOPUS
Bibliographic Citation
Annals of Tropical Medicine and Parasitology. Vol.97, No.8 (2003), 847-853
Suggested Citation
C. Sirivichayakul, C. Pojjaroen-Anant, P. Wisetsing, R. Praevanit, P. Chanthavanich, K. Limkittikul The effectiveness of 3, 5 or 7 days of albendazole for the treatment of Trichuris trichiura infection. Annals of Tropical Medicine and Parasitology. Vol.97, No.8 (2003), 847-853. doi:10.1179/000349803225002480 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/20859
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Title
The effectiveness of 3, 5 or 7 days of albendazole for the treatment of Trichuris trichiura infection
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Abstract
A randomized clinical trial was carried out to study the relationship between the duration of albendazole therapy, at 400 mg/day, and its effectiveness in the treatment of Trichuris trichiura infection. The 168 patients were treated for three (N = 56), five (N = 56) or seven (N = 56) consecutive days. Compared with both of the shorter regimens, treatment for 7 days resulted in a significantly higher cure 'rate' and significantly greater reductions in the level of egg excretion. The advantage of using the longer (5- or 7-day) regimens was most apparent among the patients who had heavy infections (at least 1000 Trichuris eggs/g faeces) when treated. It is therefore suggested that albendazole be given for at least 3 days to those with light infections and for 5-7 days to patients with heavy infections.