Publication: Contribution to Malaria Transmission of Symptomatic and Asymptomatic Parasite Carriers in Cambodia
Issued Date
2018-04-23
Resource Type
ISSN
15376613
00221899
00221899
Other identifier(s)
2-s2.0-85045924875
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Infectious Diseases. Vol.217, No.10 (2018), 1561-1568
Suggested Citation
Amélie Vantaux, Reingsey Samreth, Eakpor Piv, Nimol Khim, Saorin Kim, Laura Berne, Sophy Chy, Dysoley Lek, Sovannaroth Siv, Walter R. Taylor, Didier Ménard Contribution to Malaria Transmission of Symptomatic and Asymptomatic Parasite Carriers in Cambodia. Journal of Infectious Diseases. Vol.217, No.10 (2018), 1561-1568. doi:10.1093/infdis/jiy060 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/46748
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Title
Contribution to Malaria Transmission of Symptomatic and Asymptomatic Parasite Carriers in Cambodia
Abstract
© The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. Background Eliminating falciparum malaria in Cambodia is a top priority, requiring the implementation of novel tools and strategies to interrupt its transmission. To date, few data are available regarding the contributions to malaria transmission of symptomatic and asymptomatic carriers. Methods Direct-membrane and skin feeding assays (DMFAs, SFAs) were performed, using Anopheles minimus and Anopheles dirus, to determine infectivity of symptomatic falciparum-infected patients and malaria asymptomatic carriers; a subset of the latter were followed up for 2 months to assess their transmission potential. Results By microscopy and real-time polymerase chain reaction, Plasmodium falciparum gametocyte prevalence rates were, respectively, 19.3% (n = 21/109) and 44% (n = 47/109) on day (D) 0 and 17.9% (n = 5/28) and 89.3% (n = 25/28) in recrudescent patients (Drec) (RT-PCR Drec vs D0 P =.002). Falciparum malaria patient infectivity was low on D0 (6.2%; n = 3/48) and in Drec (8.3%; n = 1/12). Direct-membrane feeding assays and SFAs gave similar results. None of the falciparum (n = 0/19) and 3 of 28 Plasmodium vivax asymptomatic carriers were infectious to mosquitoes, including those that were followed up for 2 months. Overall, P. falciparum gametocytemias were low except in a few symptomatic carriers. Conclusions Only symptomatic falciparum malaria patients were infectious to mosquito vectors at baseline and recrudescence, highlighting the need to detect promptly and treat effectively P. falciparum patients.