Publication: Effect of resorbable collagen plug on bone regeneration in rat critical-size defect model
Issued Date
2016-04-13
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ISSN
10566163
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2-s2.0-84959156461
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Mahidol University
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SCOPUS
Bibliographic Citation
Implant Dentistry. Vol.25, No.2 (2016), 163-170
Suggested Citation
Weiqing Liu, Ning Kang, Yuliang Dong, Yuchen Guo, Dan Zhao, Shiwen Zhang, Liyan Zhou, Dutmanee Seriwatanachai, Xing Liang, Quan Yuan Effect of resorbable collagen plug on bone regeneration in rat critical-size defect model. Implant Dentistry. Vol.25, No.2 (2016), 163-170. doi:10.1097/ID.0000000000000396 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/43550
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Title
Effect of resorbable collagen plug on bone regeneration in rat critical-size defect model
Abstract
© 2016 Wolters Kluwer Health, Inc. All rights reserved. Objective: The purpose of this investigation was to examine the effect of resorbable collagen plug (RCP) on bone regeneration in rat calvarial critical-size defects. Methods: About 5-mm-diameter calvarial defects were created in forty 12-week-old male Sprague-Dawley rats and implanted with or without RCP. Animals were killed at 1, 2, 4, and 8 weeks postoperatively. After being killed, specimens were collected and subjected to microcomputed tomography (mCT) and histological analysis. Results: The mCT showed a significant increase of newly formed bone volume/tissue volume in RCPimplanted defect compared with controls at all designated time points. After 8 weeks, the defects implanted with RCP displayed almost complete closure. Hematoxylin and eosin staining of the decalcified sections confirmed these observations and evidenced active bone regeneration in the RCP group. In addition, Masson's trichrome staining demonstrated that RCP implantation accelerated the process of collagen maturation. Conclusions: The RCP enhances bone regeneration in rat criticalsize cranial defects, which suggest it might be a desired material for bone defect repair.