Publication: Washout of mass-like benign breast lesions at dynamic magnetic resonance imaging
Issued Date
2012-05-01
Resource Type
ISSN
15323145
03638715
03638715
Other identifier(s)
2-s2.0-84861515184
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Computer Assisted Tomography. Vol.36, No.3 (2012), 301-305
Suggested Citation
Penampai Tannaphai, Rubina Manuela Trimboli, Luca Alessandro Carbonaro, Sara Viganò, Giovanni Di Leo, Francesco Sardanelli Washout of mass-like benign breast lesions at dynamic magnetic resonance imaging. Journal of Computer Assisted Tomography. Vol.36, No.3 (2012), 301-305. doi:10.1097/RCT.0b013e3182506c48 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/14824
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Washout of mass-like benign breast lesions at dynamic magnetic resonance imaging
Other Contributor(s)
Abstract
Objective: This study aimed to estimate the frequency and timing of washout in a series of pathologically proven benign mass-like breast lesions at dynamic magnetic resonance imaging. Methods: Institutional review board approval was obtained for this retrospective study. We evaluated enhancement kinetics of 33 pathologically confirmed benign breast lesions: fibroadenomas (n = 22), adenosis (n = 6), typical ductal hyperplasia (n = 2), fibroadenoma with ductal hyperplasia (n = 1), fibrosclerosis (n = 1), and inflammatory lesion (n = 1). Coronal 3-dimensional T1-weighted gradient-echo sequences were acquired before/after intravenous injection of 0.1 mmol/ kg gadoterate meglumine (time resolution, 111 seconds), 1 before and 5 after contrast injection. The time point at which the kinetic curve demonstrated a washout was recorded. Cumulative distribution of lesions showing washout was built. Paired comparisons of specificity for washout kinetics were performed using the McNemar test. Results: Of 33 lesions, washout was never observed in 20 (61%), whereas 13 (39%) showed washout during the study. Of these 13 lesions, only 1 (inflammatory mass) exhibited washout within the first 3 minutes (specificity, 97%), 9 within 6 minutes (specificity, 73%), and 13 within 8 minutes (specificity, 61%). Specificity of washout kinetics within 3 minutes (97%) was significantly larger than that from the sixth minute (73%) and thereafter (P < 0.016). Conclusions: A prolonged observation for dynamic breast magnetic resonance imaging may result in false-positive washout, especially after 6 minutes. Late washout should not be considered a reliable marker of malignancy. Copyright © 2012 by Lippincott Williams & Wilkins.