Publication: Genomic characterization of non-O1, non-O139 Vibrio cholerae reveals genes for a type III secretion system
Issued Date
2005-03-01
Resource Type
Language
eng
Rights
Mahidol University
Bibliographic Citation
PNAS. Vol.102, No.9 (2005), 3465-3470
Suggested Citation
Michelle Dziejman, Davide Serruto, Vincent C. Tam, Derek Sturtevant, Pornphan Diraphat, Shah M. Faruque, M. Hasibur Rahman, John F. Heidelberg, Jeremy Decker, Li Li, Kate T. Montgomery, George Grills, Raju Kucherlapati, John J. Mekalanos Genomic characterization of non-O1, non-O139 Vibrio cholerae reveals genes for a type III secretion system. PNAS. Vol.102, No.9 (2005), 3465-3470. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/2474
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Genomic characterization of non-O1, non-O139 Vibrio cholerae reveals genes for a type III secretion system
Other Contributor(s)
Abstract
Non-O1, non-O139 Vibrio cholerae can cause gastroenteritis and extraintestinal infections, but, unlike
O1 and O139 strains of V. cholerae, little is known about the virulence gene content of non-O1, non-O139
strains and their phylogenetic relationship to other pathogenic V. cholerae. Comparative genomic microarray
analysis of four pathogenic non-O1, non-O139 strains indicates that these strains are quite divergent from O1
and O139 strains. Genomic sequence analysis of a non-O1, non-O139 strain (AM-19226) that appeared
particularly pathogenic in experimental animals suggests that this strain carries a type III secretion system
(TTSS) that is related to the TTSS2 gene cluster found in a pandemic clone of Vibrio parahaemolyticus. The
genes for this V. cholerae TTSS system appear to be present in many clinical and environmental non-O1, non-
O139 strains, including at least one clone that is globally distributed. We hypothesize that the TTSS present in
some pathogenic strains of non-O1, non-O139 V. cholerae may be involved in the virulence and environmental
fitness of these strains.