Publication: Leukotriene receptor antagonists inhibit mitogenic activity in triple negative breast cancer cells
Issued Date
2018-03-01
Resource Type
ISSN
2476762X
15137368
15137368
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2-s2.0-85044354383
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Mahidol University
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SCOPUS
Bibliographic Citation
Asian Pacific Journal of Cancer Prevention. Vol.19, No.3 (2018), 833-837
Suggested Citation
Kran Suknuntha, Ruedeemars Yubolphan, Kanokpan Krueaprasertkul, Sirada Srihirun, Nathawut Sibmooh, Pornpun Vivithanaporn Leukotriene receptor antagonists inhibit mitogenic activity in triple negative breast cancer cells. Asian Pacific Journal of Cancer Prevention. Vol.19, No.3 (2018), 833-837. doi:10.22034/APJCP.2018.19.3.833 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/45210
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Title
Leukotriene receptor antagonists inhibit mitogenic activity in triple negative breast cancer cells
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Abstract
© Asian Pacific Journal of Cancer Prevention, 2017. Despite a discovery of hormonal pathways regulating breast cancer, a definitive cure for the disease requires further identification of alternative targets that provide a hormone-independent support. Apart from their role in inflammatory diseases, cysteinyl leukotriene (CysLT) receptor antagonists (LTRAs) decrease the risk of lung cancer in asthma patients and inhibit tumor progression in several malignancies. In the present study, we evaluate the effects of two chemically different, clinically relevant LTRAs (montelukast and zafirlukast) in a triple negative breast cancer cell line, MDAMB- 231. We found that these two LTRAs reduced breast cancer cell viability in a dose-dependent manner with the 50% inhibitory concentration (IC50) between 5-10 μM. Although both LTRAs have several pharmacological properties in common, we noticed that montelukast mainly induced apoptosis, while zafirlukast mainly exerted its action on cell cycle. However, the precise mechanisms responsible for such different effects remain unclear. In summary, our results suggest that CysLT plays a role in proliferation and survivability of breast cancer cells in the absence of hormonal stimuli.