Publication: Plant Antitumor Agents. 31. The Calycopterones, a New Class of Biflavonoids with Novel Cytotoxicity in a Diverse Panel of Human Tumor Cell Lines
Issued Date
1994-05-01
Resource Type
ISSN
15204804
00222623
00222623
Other identifier(s)
2-s2.0-0028318867
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Medicinal Chemistry. Vol.37, No.10 (1994), 1465-1470
Suggested Citation
Monroe E. Wall, Mansukh C. Wani, Fekadu Fullas, John B. Oswald, Dan M. Brown, Thawatchai Santisuk, Vichai Reutrakul, Andrew T. McPhail, Norman R. Farnsworth, John M. Pezzuto, A. Douglas Kinghorn, Jeffrey M. Besterman Plant Antitumor Agents. 31. The Calycopterones, a New Class of Biflavonoids with Novel Cytotoxicity in a Diverse Panel of Human Tumor Cell Lines. Journal of Medicinal Chemistry. Vol.37, No.10 (1994), 1465-1470. doi:10.1021/jm00036a012 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/9513
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Title
Plant Antitumor Agents. 31. The Calycopterones, a New Class of Biflavonoids with Novel Cytotoxicity in a Diverse Panel of Human Tumor Cell Lines
Abstract
Three new biflavonoids to which we have accorded the trivial names calycopterone (1), isocalycopterone (2), and 4-demethylcalycopterone (3) and the known flavone 4′,5-dihydroxy-3,3′,6,7-tetramethoxyflavone (4) were isolated as cytotoxic constituents from the flowers of Calycopteris floribunda Lamk. (Combretaceae). Compounds 1–3 showed a wide range of activity against a panel of solid tumor cell lines. Among the biflavonoids, calycopterone (1) is the major constituent. © 1994, American Chemical Society. All rights reserved.