Publication: Association of HLA genotypes with Beta-lactam antibiotic hypersensitivity in children
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Issued Date
2021-09-01
Resource Type
ISSN
22288694
0125877X
0125877X
Other identifier(s)
2-s2.0-85117538082
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Mahidol University
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SCOPUS
Bibliographic Citation
Asian Pacific Journal of Allergy and Immunology. Vol.39, No.3 (2021), 197-205
Suggested Citation
Prapasiri Singvijarn, Wiparat Manuyakorn, Surakameth Mahasirimongkol, Sukanya Wattanapokayakit, Wimala Inunchot, Nuanjun Wichukchinda, Supharat Suvichapanich, Wasu Kamchaisatian, Suwat Benjaponpitak Association of HLA genotypes with Beta-lactam antibiotic hypersensitivity in children. Asian Pacific Journal of Allergy and Immunology. Vol.39, No.3 (2021), 197-205. doi:10.12932/AP-271118-0449 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/77221
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Title
Association of HLA genotypes with Beta-lactam antibiotic hypersensitivity in children
Abstract
Background: Beta-lactam (BL) antibiotics hypersensitivity is common in children. Clinical manifestation of BL hypersensitivity varies from mild to severe cutaneous adverse drug reactions (SCARs). Objective: To determine the association of HLA genotype and BL hypersensitivity and the prevalence of true drug allergy in patients with history of BL hypersensitivity. Methods: A case-control study was performed in 117 children with aged 1-18 years. Children with history of non-SCARs BL hypersensitivity were evaluated for true drug hypersensitivity including skin test and drug provocation test. Tolerant control patients were children who could tolerate BL for at least 7 days without hypersensitivity reaction. HLA genotype (HLA-A, HLA-B, HLA-C and HLA-DRB1) were performed in 24 cases and 93 tolerant controls using PCR-SSO (polymerase chain reaction – sequence specific oligonucleotide probes). Results: There were association of HLA-C*04:06 (OR = 13.14, 95%CI: 1.3-137.71; p = 0.027), and HLA-C*08:01 (OR = 4.83, 95%CI: 1.93-16.70; p = 0.016) with BL hypersensitivity. HLA-B*48:01 was strongly associated with immediate reaction from BL hypersensitivity (OR = 37.4, 95%CI: 1.69-824.59; p = 0.016) while HLA-C*04:06, HLA-C*08:01 and HLA-DRB1*04:06 were associated with delayed reaction (p < 0.05). Among 71 cases who were newly evaluated for BL hypersensitivity, only 7 cases (9.8%) had true BL hypersensitivity. Conclusions: Less than 10% of children with suspected of BL hypersensitivity have true hypersensitivity. There migbe a role of HLA-B, HLA-C and HLA-DRB1 genotype in predicting BL hypersensitivity in Thai children.