Publication: Molecular Evidence of Rickettsia in Human and Dog Blood in Bangkok
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Issued Date
2018-06-01
Resource Type
ISSN
15577759
15303667
15303667
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2-s2.0-85048218008
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Mahidol University
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SCOPUS
Bibliographic Citation
Vector-Borne and Zoonotic Diseases. Vol.18, No.6 (2018), 297-302
Suggested Citation
Nanthanida Mongkol, Yupin Suputtamongkol, Piyanan Taweethavonsawat, Suporn Foongladda Molecular Evidence of Rickettsia in Human and Dog Blood in Bangkok. Vector-Borne and Zoonotic Diseases. Vol.18, No.6 (2018), 297-302. doi:10.1089/vbz.2017.2180 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/46010
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Title
Molecular Evidence of Rickettsia in Human and Dog Blood in Bangkok
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Abstract
© Copyright 2018, Mary Ann Liebert, Inc. Rickettsia spp. has been detected in dog fleas in Bangkok, Thailand. With the intent of collecting evidence to confirm the presence of rickettsioses in dogs and to assess the level of associated potential for accidental human infection, human buffy coat from patients with fever of unknown origin (n = 168), whole blood samples from dogs (n = 353), and 19 flea groups from our dog sample population were studied during the 2012 to 2014 study period. The presence of Rickettsia was investigated by molecular detection of 23S rRNA gene of Rickettsia genus, citrate synthase (gltA) gene, and 17-kDa outer membrane gene. All positive samples were confirmed by DNA sequence analysis. Using phylogenetic analysis, three groups of Rickettsia were detected, as follows: Rickettsia felis in 8 patients and 8 dogs; R. felis-like sp. in 2 patients, 5 dogs, and 11 flea samples; and Rickettsia typhi in 3 patients. In addition to confirming the presence of R. felis in Thai patients, the findings of this study suggest that R. felis-like sp. isolated from fleas that were symbiotically coexisting with dogs that we evaluated in this study can transmit and cause disease in dogs and humans in Bangkok.