Publication: Streptozotocin induces alpha-2u globulin nephropathy in male rats during diabetic kidney disease
Issued Date
2021-12-01
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17466148
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2-s2.0-85101967397
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Mahidol University
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SCOPUS
Bibliographic Citation
BMC Veterinary Research. Vol.17, No.1 (2021)
Suggested Citation
Kanchana Kengkoom, Wannee Angkhasirisap, Tapanee Kanjanapruthipong, Rongdej Tungtrakanpoung, Khwanchanok Tuentam, Naphatson Phansom, Sumate Ampawong Streptozotocin induces alpha-2u globulin nephropathy in male rats during diabetic kidney disease. BMC Veterinary Research. Vol.17, No.1 (2021). doi:10.1186/s12917-021-02814-z Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/79143
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Title
Streptozotocin induces alpha-2u globulin nephropathy in male rats during diabetic kidney disease
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Abstract
Background: Alpha-2u globulin nephropathy mainly shows toxicological pathology only in male rats induced by certain chemicals and drugs, such as levamisole (antiparasitic and anticancer drugs). Streptozotocin (STZ) is also an anticancer-antibiotic agent that has been used for decades to induce a diabetic kidney disease model in rodents. The purpose of this study is to determine if STZ causes alpha-2u globulin nephropathy in male rats during an advanced stage of diabetic kidney disease. Alpha-2u globulin nephropathy, water absorption and filtration capacities (via aquaporin [AQP]-1, − 2, − 4 and − 5) and mitochondrial function (through haloacid dehalogenase-like hydrolase domain-containing protein [HDHD]-3 and NADH-ubiquinone oxidoreductase 75 kDa subunit [NDUFS]-1 proteins) were examined in STZ-induced diabetic Wistar rat model. Results: More than 80% of severe clinical illness rats induced by STZ injection simultaneously exhibited alpha-2u globulin nephropathy with mitochondrial degeneration and filtration apparatus especially pedicels impairment. They also showed significantly upregulated AQP-1, − 2, − 4 and − 5, HDHD-3 and NDUFS-1 compared with those of the rats without alpha-2u globulin nephropathy. Conclusions: STZ-induced alpha-2u globulin nephropathy during diabetic kidney disease in association with deterioration of pedicels, renal tubular damage with adaptation and mitochondrial driven apoptosis.