Publication:
Impairment of acetylcholine synthesis in thiamine deficient rats developed by prolonged tea consumption

Issued Date

1984-01-23

Resource Type

Article

ISSN

00243205

DOI

10.1016/0024-3205(84)90625-8

Other identifier(s)

2-s2.0-0021350958

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Life Sciences. Vol.34, No.4 (1984), 365-370

Suggested Citation

Pintip Ruenwongsa, Supakorn Pattanavibag Impairment of acetylcholine synthesis in thiamine deficient rats developed by prolonged tea consumption. Life Sciences. Vol.34, No.4 (1984), 365-370. doi:10.1016/0024-3205(84)90625-8 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/30709

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Title

Impairment of acetylcholine synthesis in thiamine deficient rats developed by prolonged tea consumption

Author(s)

Pintip Ruenwongsa
 Supakorn Pattanavibag

Other Contributor(s)

Mahidol University

Abstract

The synthesis of whole brain acetylcholine is reduced in thiamine deficient rats produced by prolonged administration of tea. In those rats fed a normal diet and given tea (1:50, w/v) instead of drinking water for 20 weeks, the conversion of [14C] pyruvate to [14C] acetylcholine decreased by 35%. However, no neurological symptoms were observed. Administration of tea to rats fed a thiamine half-deficient diet for 7-8 weeks caused not only 60% decrease in acetylcholine synthesis but also neurological symptoms. This decreased synthesis of acetylcholine is related to a decline in pyruvate dehydrogenase activity. The results suggest that prolonged administration of tea to rats cause an impairment of acetyl CoA production resulting in a deficit in acetylcholine synthesizing capacity. © 1984.

Keyword(s)

Pharmacology, Toxicology and Pharmaceutics

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URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/30709

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Scopus 1969-1990