Publication:
Artesunate-tafenoquine combination therapy promotes clearance and abrogates transmission of the avian malaria parasite Plasmodium gallinaceum

dc.contributor.authorSuchada Tasaien_US
dc.contributor.authorTawee Saiwichaien_US
dc.contributor.authorMorakot Kaewthamasornen_US
dc.contributor.authorSonthaya Tiawsirisupen_US
dc.contributor.authorPrayute Buddhirakkulen_US
dc.contributor.authorSirintip Chaichalotornkulen_US
dc.contributor.authorSittiporn Pattaradilokraten_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherChulalongkorn Universityen_US
dc.contributor.otherMae Fah Luang Universityen_US
dc.date.accessioned2018-12-21T08:02:59Z
dc.date.accessioned2019-03-14T08:03:50Z
dc.date.available2018-12-21T08:02:59Z
dc.date.available2019-03-14T08:03:50Z
dc.date.issued2017-01-15en_US
dc.description.abstract© 2016 Elsevier B.V. Clinical manifestations of malaria infection in vertebrate hosts arise from the multiplication of the asexual stage parasites in the blood, while the gametocytes are responsible for the transmission of the disease. Antimalarial drugs that target the blood stage parasites and transmissible gametocytes are rare, but are essentially needed for the effective control of malaria and for limiting the spread of resistance. Artemisinin and its derivatives are the current first-line antimalarials that are effective against the blood stage parasites and gametocytes, but resistance to artemisinin has now emerged and spread in various malaria endemic areas. Therefore, a novel antimalarial drug, or a new drug combination, is critically needed to overcome this problem. The objectives of this study were to evaluate the efficacy of a relatively new antimalarial compound, tafenoquine (TQ), and a combination of TQ and a low dose of artesunate (ATN) on the in vivo blood stage multiplication, gametocyte development and transmission of the avian malaria parasite Plasmodium gallinaceum to the vector Aedes aegypti. The results showed that a 5-d treatment with TQ alone was unable to clear the blood stage parasites, but was capable of reducing the mortality rate, while TQ monotherapy at a high dose of 30 mg/kg was highly effective against the gametocytes and completely blocked the transmission of P. gallinaceum. In addition, the combination therapy of TQ + ATN completely cleared P. gallinaceum blood stages and sped up the gametocyte clearance from chickens, suggesting the synergistic effect of the two drugs. In conclusion, TQ is demonstrated to be effective for limiting avian malaria transmission and may be used in combination with a low dose of ATN for safe and effective treatment.en_US
dc.identifier.citationVeterinary Parasitology. Vol.233, (2017), 97-106en_US
dc.identifier.doi10.1016/j.vetpar.2016.12.008en_US
dc.identifier.issn18732550en_US
dc.identifier.issn03044017en_US
dc.identifier.other2-s2.0-85006992960en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/42806
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85006992960&origin=inwarden_US
dc.subjectImmunology and Microbiologyen_US
dc.titleArtesunate-tafenoquine combination therapy promotes clearance and abrogates transmission of the avian malaria parasite Plasmodium gallinaceumen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85006992960&origin=inwarden_US

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