Publication: Pitfalls in estimating piperaquine elimination
Issued Date
2005-12-01
Resource Type
ISSN
00664804
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2-s2.0-28844503112
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Mahidol University
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SCOPUS
Bibliographic Citation
Antimicrobial Agents and Chemotherapy. Vol.49, No.12 (2005), 5127-5128
Suggested Citation
Joel Tarning, Niklas Lindegårdh, Anna Annerberg, Thida Singtoroj, Nicholas P.J. Day, Michael Ashton, Nicholas J. White Pitfalls in estimating piperaquine elimination. Antimicrobial Agents and Chemotherapy. Vol.49, No.12 (2005), 5127-5128. doi:10.1128/AAC.49.12.5127-5128.2005 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/16719
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Title
Pitfalls in estimating piperaquine elimination
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Abstract
By using a sensitive new assay, the terminal elimination half-life of the antimalarial piperaquine in a healthy volunteer was estimated to be 33 days, which is longer than estimated previously. This result illustrates the importance of extended sampling duration and sensitive assay methodologies in characterizing the disposition of slowly eliminated antimalarial drugs. Copyright © 2005, American Society for Microbiology. All Rights Reserved.