Publication: Antioxidant and anticholinesterase activities of extracts and phytochemicals of syzygium antisepticum leaves
4
Issued Date
2021-06-01
Resource Type
ISSN
14203049
Other identifier(s)
2-s2.0-85107433313
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Molecules. Vol.26, No.11 (2021)
Suggested Citation
Supachoke Mangmool, Issaree Kunpukpong, Worawan Kitphati, Natthinee Anantachoke Antioxidant and anticholinesterase activities of extracts and phytochemicals of syzygium antisepticum leaves. Molecules. Vol.26, No.11 (2021). doi:10.3390/molecules26113295 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/76159
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Antioxidant and anticholinesterase activities of extracts and phytochemicals of syzygium antisepticum leaves
Other Contributor(s)
Abstract
Bioassay-guided separation of young leaves extracts of Syzygium antisepticum (Blume) Merr. & L.M. Perry led to the isolation of four triterpenoids (betulinic acid, ursolic acid, jacoumaric acid, corosolic acid) and one sterol glucoside (daucosterol) from the ethyl acetate extract, and three polyphenols (gallic acid, myricitrin, and quercitrin) from the methanol (MeOH) extract. The MeOH extract of S. antisepticum and some isolated compounds, ursolic acid and gallic acid potentially exhibited acetylcholinesterase activity evaluated by Ellman’s method. The MeOH extract and its isolated compounds, gallic acid, myricitrin, and quercitrin, also strongly elicited DPPH radical scavenging activity. In HEK-293 cells, the MeOH extract possessed cellular antioxidant effects by attenuating hydrogen peroxide (H2O2)-induced ROS production and increasing catalase, glutathione peroxidase-1 (GPx-1), and glutathione reductase (GRe). Furthermore, myricitrin and quercitrin also suppressed ROS production induced by H2O2 and induced GPx-1 and catalase production in HEK293 cells. These results indicated that the young leaves of S. antisepticum are the potential sources of antioxidant and anticholinesterase agents. Consequently, S. antisepticum leaves are one of indigenous vegetables which advantage to promote the health and prevent diseases related to oxidative stress.