Publication: Upregulation and expression patterns of the angiogenic transcription factor Ets-1 in Alzheimer's disease brain
Issued Date
2013-01-01
Resource Type
ISSN
18758908
13872877
13872877
Other identifier(s)
2-s2.0-84883760500
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Alzheimer's Disease. Vol.37, No.2 (2013), 367-377
Suggested Citation
Nattinee Jantaratnotai, Alden Ling, Jenny Cheng, Claudia Schwab, Patrick L. Mcgeer, James G. Mclarnon Upregulation and expression patterns of the angiogenic transcription factor Ets-1 in Alzheimer's disease brain. Journal of Alzheimer's Disease. Vol.37, No.2 (2013), 367-377. doi:10.3233/JAD-122191 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/32632
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Upregulation and expression patterns of the angiogenic transcription factor Ets-1 in Alzheimer's disease brain
Other Contributor(s)
Abstract
Immunohistochemical staining has been used to determine expression patterns of the angiogenic transcription factor, Ets-1, in the brains of Alzheimer's disease (AD) individuals. Brain tissue from non-demented controls showed little expression of Ets-1 whereas in AD brain tissue, Ets-1 was ubiquitously expressed in cortex and hippocampus. Double immunostaining with von Willerbrand factor demonstrated prominent Ets-1 intravascular immunoreactivity (ir) in AD cortical microvessels. In addition, Ets-1 also exhibited extravascular expression characterized by a diffuse pattern of Ets-1 ir in AD brain. Double staining also showed Ets-1 colocalization in microvasculature with the potent angiogenic agent, vascular endothelial growth factor (VEGF). Cell-associated tumor necrosis factor-α (TNF-α), a pro-inflammatory cytokine with pro-angiogenic activity, was primarily associated with diffuse extravascular Ets-1 ir. Clusters of HLA-DR positive microglia, resident immune cells of brain which release TNF-α, were also localized with diffuse Ets-1. Intravascular Ets-1 ir was maximally co-localized with soluble amyloid-β peptide (Aβ), Aβ1-40, in microvasculature whereas diffuse extravascular Ets-1 ir appeared in proximity to Aβ plaques in brain parenchyma. Similar overall results were obtained for patterns of Ets-1 staining in AD hippocampal tissue. This work provides novel findings on expression of the angiogenic transcription factor, Ets-1, in vascular remodeling and its association with pro-angiogenic factors, reactive microglia, and Aβ deposition in AD brain. © 2013 - IOS Press and the authors. All rights reserved.