Publication: Photo-cured PMMA/PEI core/shell nanoparticles surface-modified with Gd-DTPA for T1 MR imaging
5
Issued Date
2014-02-01
Resource Type
ISSN
10957103
00219797
00219797
Other identifier(s)
2-s2.0-84887335684
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Colloid and Interface Science. Vol.415, (2014), 70-76
Suggested Citation
Montri Ratanajanchai, Don Haeng Lee, Panya Sunintaboon, Su Geun Yang Photo-cured PMMA/PEI core/shell nanoparticles surface-modified with Gd-DTPA for T1 MR imaging. Journal of Colloid and Interface Science. Vol.415, (2014), 70-76. doi:10.1016/j.jcis.2013.09.049 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/33575
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Title
Photo-cured PMMA/PEI core/shell nanoparticles surface-modified with Gd-DTPA for T1 MR imaging
Abstract
Herein, we introduced amine-functionalized core-shell nanoparticles (Polymethyl methacrylate/Polyethyleneimine; PMMA/PEI) with surface primary amines (3.15×105groups/particle) and uniform size distribution (150-200nm) that were prepared by one-step photo-induced emulsion polymerization. Further PEI-surface was modified with diethylenetriamine pentaacetic acid (DTPA) and introduced with Gd(III). The modified particles possessing DTPA can entrap a high content of Gd(III) ions of over 5.5×104Gd/particle with stable chelation (no release of free Gd) at least 7h. The Gd-DTPA-conjugated core-shell nanoparticles (PMMA/PEI-DTPA-Gd NPs) enhanced the MRI intensity more than Primovist (a commercial hepatic contrast agent). Moreover, the PMMA/PEI-DTPA-Gd NPs showed non-cytotoxicity up to 250μM in normal liver cells. Thus, in vitro data suggested the PMMA/PEI-DTPA-Gd NPs is promising delivery system as a superior MRI contrast agent, especially for hepatic lesion targeted MR imaging. © 2013 Elsevier Inc.