Publication:
Molecular Surveillance Identifies Multiple Transmissions of Typhoid in West Africa

Issued Date

2016-09-22

Resource Type

Article

ISSN

19352735
19352727

DOI

10.1371/journal.pntd.0004781

Other identifier(s)

2-s2.0-84992386056

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

PLoS Neglected Tropical Diseases. Vol.10, No.9 (2016)

Suggested Citation

Vanessa K. Wong, Kathryn E. Holt, Chinyere Okoro, Stephen Baker, Derek J. Pickard, Florian Marks, Andrew J. Page, Grace Olanipekun, Huda Munir, Roxanne Alter, Paul D. Fey, Nicholas A. Feasey, François Xavier Weill, Simon Le Hello, Peter J. Hart, Samuel Kariuki, Robert F. Breiman, Melita A. Gordon, Robert S. Heyderman, Jan Jacobs, Octavie Lunguya, Chisomo Msefula, Calman A. MacLennan, Karen H. Keddy, Anthony M. Smith, Robert S. Onsare, Elizabeth De Pinna, Satheesh Nair, Ben Amos, Gordon Dougan, Stephen Obaro, Julian Parkhill, Robert A. Kingsley, Nicholas R. Thomson, Jacqueline A. Keane, Jane Hawkey, David J. Edwards, Zoe A. Dyson, Simon R. Harris, Amy K. Cain, James Hadfield, Elizabeth J. Klemm, Conall H. Watson, W. John Edmunds, Nga Tran Vu Thieu, Mike Kama, Kylie Jenkins, Shanta Dutta, Josefina Campos, Corinne Thompson, Christiane Dolecek, Christopher M. Parry, Abhilasha Karkey, E. Kim Mulholland, James I. Campbell, Sabina Dongol, Buddha Basnyat, Amit Arjyal, Muriel Dufour, Don Bandaranayake, Take N. Toleafoa, Shalini Pravin Singh, Mochammad Hatta, Lupeoletalalelei Isaia Molecular Surveillance Identifies Multiple Transmissions of Typhoid in West Africa. PLoS Neglected Tropical Diseases. Vol.10, No.9 (2016). doi:10.1371/journal.pntd.0004781 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/41138

Research Projects

Organizational Units

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Journal Issue

Thesis

Title

Molecular Surveillance Identifies Multiple Transmissions of Typhoid in West Africa

Author(s)

Vanessa K. Wong
 Kathryn E. Holt
 Chinyere Okoro
 Stephen Baker
 Derek J. Pickard
 Florian Marks
 Andrew J. Page
 Grace Olanipekun
 Huda Munir
 Roxanne Alter
 Paul D. Fey
 Nicholas A. Feasey
 François Xavier Weill
 Simon Le Hello
 Peter J. Hart
 Samuel Kariuki
 Robert F. Breiman
 Melita A. Gordon
 Robert S. Heyderman
 Jan Jacobs
 Octavie Lunguya
 Chisomo Msefula
 Calman A. MacLennan
 Karen H. Keddy
 Anthony M. Smith
 Robert S. Onsare
 Elizabeth De Pinna
 Satheesh Nair
 Ben Amos
 Gordon Dougan
 Stephen Obaro
 Julian Parkhill
 Robert A. Kingsley
 Nicholas R. Thomson
 Jacqueline A. Keane
 Jane Hawkey
 David J. Edwards
 Zoe A. Dyson
 Simon R. Harris
 Amy K. Cain
 James Hadfield
 Elizabeth J. Klemm
 Conall H. Watson
 W. John Edmunds
 Nga Tran Vu Thieu
 Mike Kama
 Kylie Jenkins
 Shanta Dutta
 Josefina Campos
 Corinne Thompson
 Christiane Dolecek
 Christopher M. Parry
 Abhilasha Karkey
 E. Kim Mulholland
 James I. Campbell
 Sabina Dongol
 Buddha Basnyat
 Amit Arjyal
 Muriel Dufour
 Don Bandaranayake
 Take N. Toleafoa
 Shalini Pravin Singh
 Mochammad Hatta
 Lupeoletalalelei Isaia

Other Contributor(s)

Wellcome Trust Sanger Institute
 Addenbrooke's Hospital
 Bio21 Molecular Science and Biotechnology Institute
 University of Melbourne
 UCL
 Nuffield Department of Clinical Medicine
 London School of Hygiene & Tropical Medicine
 International Vaccine Institute, Seoul
 International Foundation Against Infectious Diseases in Nigeria (IFAIN)
 Aminu Kano Teaching Hospital
 University of Nebraska Medical Center
 Liverpool School of Tropical Medicine
 Institut Pasteur, Paris
 University of Birmingham
 St George's University of London
 Kenya Medical Research Institute
 Centers for Disease Control and Prevention
 Emory Global Health Institute
 University of Liverpool
 University of Malawi College of Medicine
 Prins Leopold Instituut voor Tropische Geneeskunde
 KU Leuven
 National Institute for Biomedical Research
 University Hospital of Kinshasa
 University of Witwatersrand
 Public Health England
 St Augustine's Hospital
 University of Abuja
 Bingham University
 Quadram Institute Bioscience
 Universidad de la Republica Instituto de Higiene
 Ministry of Health
 Fiji Health Sector Support Program
 National Institute of Cholera and Enteric Diseases India
 ANLIS-Carlos G Malbran Institute
 Nagasaki University
 Oxford University Clinical Research Unit
 Murdoch Children's Research Institute
 Institute of Environmental Science and Research Limited (ESR)
 ESR - Kenepuru Science Centre
 Samoa Ministry of Health
 Organisation Mondiale de la Sante
 Hasanuddin University
 Tupua Tamasese Meaole Hospital
 Mahidol University
 Angkor Hospital for Children
 University of Otago
 Cardiff University
 Barts and The London NHS Trust
 University of Cambridge

Abstract

© 2016 Public Library of Science. All rights reserved. Background: The burden of typhoid in sub-Saharan African (SSA) countries has been difficult to estimate, in part, due to suboptimal laboratory diagnostics. However, surveillance blood cultures at two sites in Nigeria have identified typhoid associated with Salmonella enterica serovar Typhi (S. Typhi) as an important cause of bacteremia in children. Methods: A total of 128 S. Typhi isolates from these studies in Nigeria were whole-genome sequenced, and the resulting data was used to place these Nigerian isolates into a worldwide context based on their phylogeny and carriage of molecular determinants of antibiotic resistance. Results: Several distinct S. Typhi genotypes were identified in Nigeria that were related to other clusters of S. Typhi isolates from north, west and central regions of Africa. The rapidly expanding S. Typhi clade 4.3.1 (H58) previously associated with multiple antimicrobial resistances in Asia and in east, central and southern Africa, was not detected in this study. However, antimicrobial resistance was common amongst the Nigerian isolates and was associated with several plasmids, including the IncHI1 plasmid commonly associated with S. Typhi. Conclusions: These data indicate that typhoid in Nigeria was established through multiple independent introductions into the country, with evidence of regional spread. MDR typhoid appears to be evolving independently of the haplotype H58 found in other typhoid endemic countries. This study highlights an urgent need for routine surveillance to monitor the epidemiology of typhoid and evolution of antimicrobial resistance within the bacterial population as a means to facilitate public health interventions to reduce the substantial morbidity and mortality of typhoid.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/41138

Collections

Scopus 2016-2017