Publication: Analysis of KIR genes in HLA-identical sibling hematopoietic stem cell transplantation in Thai patients with Leukemia
3
item.page.dc.date.issued
2012-10-01
item.page.dc.type
item.page.dc.identifier.issn
01252208
item.page.dc.identifier.other
2-s2.0-84869195931
item.page.dc.rights
Mahidol University
item.page.dc.rights.holder
SCOPUS
item.page.dc.identifier.citation
Journal of the Medical Association of Thailand. Vol.95, No.10 (2012), 1261-1265
punsarn.item.page.citation
Natta Wongwuttisaroj, Sasijit Vejbaesya, Viroje Chongkolwatana, Surapol Issaragrisil Analysis of KIR genes in HLA-identical sibling hematopoietic stem cell transplantation in Thai patients with Leukemia. Journal of the Medical Association of Thailand. Vol.95, No.10 (2012), 1261-1265. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/14599
Research Projects
Organizational Units
Authors
Journal Issue
relationships.isThesisOf
item.page.dc.title
Analysis of KIR genes in HLA-identical sibling hematopoietic stem cell transplantation in Thai patients with Leukemia
item.page.dc.contributor.author
item.page.dc.contributor.other
item.page.dc.description.abstract
Background: Killer cell immunoglobulin-like receptors (KIRs) are members of a group of regulatory molecules found on the natural killer (NK) cells that regulate NK cells function by interacting with the human leukocyte antigen (HLA) class I molecules or ligands. The effects of KIR genes on the outcome of hematopoietic stem cell transplantation (HSCT) are still controversial. Objective: To investigate the distribution of KIR genes in HLA-identical sibling and the effect of KIR genes on the outcome of HSCT. Material and Method: The present study included 74 patients and their HLA-identical sibling donors. KIR genes and HLA ligands typing were determined by polymerase chain reaction-sequence specific primer (PCR-SSP). A retrospective study was carried out to analyze the outcomes of the recipients. Results: There was no effect of KIR gene mismatch and missing ligand on the outcome regarding graft-versus host disease (GVHD), relapse, and overall survival (OS) (p > 0.05). However, the presence of donor activating KIR2DS5 was associated with decreased aGVHD (p = 0.01). Conclusion: Our findings suggest an important role of donor activating KIR in identical sibling HSCT.