Publication: Copper-Catalyzed Regioselective Direct C–H Thiolation and Thiocyanation of Uracils
Issued Date
2019-04-30
Resource Type
ISSN
10990690
1434193X
1434193X
Other identifier(s)
2-s2.0-85063809200
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
European Journal of Organic Chemistry. Vol.2019, No.16 (2019), 2759-2766
Suggested Citation
Medena Noikham, Sirilata Yotphan Copper-Catalyzed Regioselective Direct C–H Thiolation and Thiocyanation of Uracils. European Journal of Organic Chemistry. Vol.2019, No.16 (2019), 2759-2766. doi:10.1002/ejoc.201900343 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/50570
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Copper-Catalyzed Regioselective Direct C–H Thiolation and Thiocyanation of Uracils
Author(s)
Other Contributor(s)
Abstract
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim A novel copper-catalyzed direct C–H thiolation and thiocyanation of uracils using disulfides and thiocyanate salts respectively as coupling partners are described. These reactions enable the C–H bond cleavage and C–S bond formation to proceed efficiently under relatively mild conditions, providing useful methods for a preparation of a series of thio-substituted at the C5 position of uracil derivatives. These protocols exhibit several merits including simple experimental procedures, readily accessible substrates and reagents, broad scopes, high yields, and excellent regioselectivity. Preliminary mechanistic studies revealed that a radical pathway is likely to be involved.