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Pulmonary edema due to oral gavage in a toxicological study related to aquaporin-1, -4 and -5 expression

dc.contributor.authorOrnuma Singhaen_US
dc.contributor.authorKanchana Kengkoomen_US
dc.contributor.authorKhuanjit Chaimongkolnukulen_US
dc.contributor.authorSompong Cherdyuen_US
dc.contributor.authorEmsri Pongponratnen_US
dc.contributor.authorTaweesak Ketjareonen_US
dc.contributor.authorYaowaluk Panavechkijkulen_US
dc.contributor.authorSumate Ampawongen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-10-19T05:14:22Z
dc.date.available2018-10-19T05:14:22Z
dc.date.issued2013-10-15en_US
dc.description.abstractA one-time oral gavage can be enough to cause of alveologenic edema with higher expression of AQP-1 and -4 than that with repeated-dose oral gavage, which caused both profound perivascular edema and hydrostatic pressure edema, while AQP-5 was similarly expressed. The alteration of AQPs expression was probably related to alveolar fluid clearance across the alveolar and bronchiolar epithelium in different stages of lung injury. The results clarified the type of lung edema in acute and sub-chronic toxicity studies without treatment related effect of tested material. The pathogenesis of pulmonary edema due to oral gavage toxicological study is associated with the cellular immune response to the reflux materials. Mast cell and leukocyte accumulation may contribute to increase vascular permeability leading to permeability edema. The increase in alveolar septum epithelium, perivascular and peribronchial cuing, accumulation alveolar lipid containing macrophage and medial hyperplasia of the pulmonary artery might have been caused to increase airway resistance, which resulted in hydrostatic pressure edema. © 2013 The Japanese Society of Toxicologic Pathology.en_US
dc.identifier.citationJournal of Toxicologic Pathology. Vol.26, No.3 (2013), 283-291en_US
dc.identifier.doi10.1293/tox.26.283en_US
dc.identifier.issn09149198en_US
dc.identifier.other2-s2.0-84885799856en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/32114
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84885799856&origin=inwarden_US
dc.subjectMedicineen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titlePulmonary edema due to oral gavage in a toxicological study related to aquaporin-1, -4 and -5 expressionen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84885799856&origin=inwarden_US
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