Publication: Effects of compression force and type of fillers on release of diclofenac sodium from matrix tablets
Issued Date
1994-01-01
Resource Type
ISSN
03639045
Other identifier(s)
2-s2.0-0028210478
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Drug Development and Industrial Pharmacy. Vol.20, No.6 (1994), 1049-1061
Suggested Citation
Narong Sarisuta, Pilawan Mahahpunt Effects of compression force and type of fillers on release of diclofenac sodium from matrix tablets. Drug Development and Industrial Pharmacy. Vol.20, No.6 (1994), 1049-1061. doi:10.3109/03639049409038350 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/9530
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Effects of compression force and type of fillers on release of diclofenac sodium from matrix tablets
Author(s)
Other Contributor(s)
Abstract
The influence of compression force and type of fillers on the release pattern of diclofenac sodium from wet-granulated tablet matrices containing Emcompress and lactose as fillers with Eudragit RSPM as a matrix additive was determined. The release pattern of diclofenac sodium from these matrices in USP phosphate buffer pH 7.2 at 37 ° C were found to be independent of compression forces whereas the ratios of insoluble (Emcompress) to soluble filler (lactose) appeared to greatly influence the drug release rate as evidenced in the increased release rate with decreasing Emcompress content. The kinetics of drug release was determined and found to precisely comform to the Higuchi's planar matrix model. A theoretical approach to predict the drug release rate from a designed system was presented and found to be satisfactorily predictive. © 1994 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.