Publication: Angiostrongylus cantonensis: Biogenic amines in the lungs of infected rats
Issued Date
1982-01-01
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ISSN
10902449
00144894
00144894
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2-s2.0-0020316604
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Mahidol University
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SCOPUS
Bibliographic Citation
Experimental Parasitology. Vol.54, No.1 (1982), 121-128
Suggested Citation
Yawaluck Tiengkamol, Chariya R. Brockelman Angiostrongylus cantonensis: Biogenic amines in the lungs of infected rats. Experimental Parasitology. Vol.54, No.1 (1982), 121-128. doi:10.1016/0014-4894(82)90118-7 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/30323
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Title
Angiostrongylus cantonensis: Biogenic amines in the lungs of infected rats
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Abstract
Levels of histamine, serotonin, norepinephrine, and dopamine were estimated sequentially in rats parasitized by the lungworm, Angiostrongylus cantonensis, between 30 and 75 days postinfection. The highest level of histamine in the infected lungs was 52.19 μg/g wet wt tissue, 13 times higher than the level found in control rats. The level of serotonin rose from the normal level of 6.41 to 10.27 μg/g wet wt tissue after the worms had lodged in the pulmonary artery for 15 days. There were no changes in norephinephrine or dopamine. Studies of host cell response to infection revealed that the increased histamine and serotonin levels corresponded to a rise in the lung population of mast cells, suggesting that these cells produced the amines. © 1982.