Publication: Drooling in Parkinson's disease: A review
Issued Date
2014-11-01
Resource Type
ISSN
18735126
13538020
13538020
Other identifier(s)
2-s2.0-84908612839
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Parkinsonism and Related Disorders. Vol.20, No.11 (2014), 1109-1118
Suggested Citation
Prachaya Srivanitchapoom, Sanjay Pandey, Mark Hallett Drooling in Parkinson's disease: A review. Parkinsonism and Related Disorders. Vol.20, No.11 (2014), 1109-1118. doi:10.1016/j.parkreldis.2014.08.013 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/34172
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Title
Drooling in Parkinson's disease: A review
Abstract
© 2014. Parkinson's disease (PD) is a neurodegenerative disease causing both motor and non-motor symptoms. Drooling, an excessive pooling and spillover of saliva out of the oral cavity, is one of the non-motor symptoms in PD patients that produces various negative physical and psychosocial consequences for patients and their caregivers. At present, the pathophysiology of drooling in PD is not completely certain; however, impaired intra-oral salivary clearance is likely the major contributor. There are neither standard diagnostic criteria nor standard severity assessment tools for evaluating drooling in PD. In accordance with the possible pathophysiology, dopaminergic agents have been used to improve salivary clearance; however, these agents are not completely effective in controlling drooling. Various pharmacological and non-pharmacological treatment options have been studied. Local injection with botulinum toxin serotypes A and B into major salivary glands is most effective to reduce drooling. Future research to explore the exact pathophysiology and develop standard diagnostic criteria and standard severity assessment tools are needed to formulate specific treatment options and improve patient care.