Publication: Risk factors for cholangiocarcinoma in Khon Kaen, Thailand: A nested case-control study
Issued Date
2009-01-01
Resource Type
ISSN
2476762X
15137368
15137368
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2-s2.0-67650917760
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Mahidol University
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SCOPUS
Bibliographic Citation
Asian Pacific Journal of Cancer Prevention. Vol.10, No.2 (2009), 251-258
Suggested Citation
Kirati Poomphakwaen, Supannee Promthet, Supot Kamsa-ard, Patravoot Vatanasapt, Wisit Chaveepojnkamjorn, Jeeranun Klaewkla, Dusit Sujirarat, Natchaporn Pichainarong Risk factors for cholangiocarcinoma in Khon Kaen, Thailand: A nested case-control study. Asian Pacific Journal of Cancer Prevention. Vol.10, No.2 (2009), 251-258. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/27334
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Title
Risk factors for cholangiocarcinoma in Khon Kaen, Thailand: A nested case-control study
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Abstract
The present nested case-control study within the Khon Kaen cohort study was conducted to assess risk factors for cholangiocarcinoma (CCA) development. Cases were 108 subjects with proven CCA by ultrasound at least and controls also numbered 108, matched by sex, age (not more than 3 years difference) and period of recruitment to the cohort (not more than 3 months difference). A questionnaire was constructed based on that employed for the Khon Kaen cohort study recruitment. McNemar's chi-square test and conditional logistic regression were used for crude analysis and multivariables analysis. Results revealed a sex ratio of 2:1 for males:females. The current study found a statistically significant association when adjusted for other potential covariate factors between cholangiocarcinoma and the consumption of total fruits 1.0-2.08 times per day (OR 0.32; 95%CI: 0.12-0.88) and history of Opisthorchis viverrini (OV) eggs in stools at recruitment plus consumption of meat < 0.45 times per day (OR 2.99; 95%CI: 1.04-8.62). The findings suggest that OV infestation is the strongest risk factor for development of cholangiocarcinoma and also suggests decrease in risk among individuals who consume more fruit.