Publication: Analgesic, anti-inflammatory and anti-ulcer properties of Thai Perilla frutescence fruit oil in animals
Issued Date
2021-01-01
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ISSN
15734935
01448463
01448463
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2-s2.0-85101336297
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Mahidol University
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SCOPUS
Bibliographic Citation
Bioscience Reports. Vol.41, No.1 (2021)
Suggested Citation
Narisara Paradee, Pimpisid Koonyosying, Winthana Kusirisin, Rattanaporn Janthip, Duangta Kanjanapothi, Kovit Pattanapanyasat, Somdet Srichairatanakool Analgesic, anti-inflammatory and anti-ulcer properties of Thai Perilla frutescence fruit oil in animals. Bioscience Reports. Vol.41, No.1 (2021). doi:10.1042/BSR20203166 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/76404
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Title
Analgesic, anti-inflammatory and anti-ulcer properties of Thai Perilla frutescence fruit oil in animals
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Abstract
Perilla frutescens fruit oil (PFO) is rich in α-linolenic acid (ALA) and exhibits biological activities. We aimed to investigate analgesic, anti-inflammatory and anti-ulcer activities of PFO and PFO-supplemented soybean milk (PFO-SM) in animal models. Analgesic activity was assessed in acetic acid-induced writhing in mice, while anti-inflammatory activity was performed in ethyl phenylpropiolate (EPP)-induced ear edema and carrageenan-induced hind paw edema in rats. Anti-ulcer effects were conducted in water immersion stress, HCl/ethanol and indomethacin-induced gastric ulcer in rats. Distinctly, PFO, containing 6.96 mg ALA and 2.61 mg LA equivalence/g, did not induce acute toxicity (LD50 > 10 mL/kg) in mice. PFO (2.5 and 5 mL/kg) and PFO-SM (0.05 mL PFO equivalence/kg) inhibited incidences of writhing (16.8, 18.0 and 32.3%, respectively) in acetic acid-induced mice. In addition, topical applications of PFO (0.1 and 1 mL/ear) significantly inhibited EPP-induced ear edema (59.3 and 65.7%, respectively) in rats, while PFO-SM slightly inhibited ear edema (25.9%). However, PFO and PFO-SM did not inhibit carrageenan-induced hind paw edema in rats. Indeed, PFO (2.5 and 5 mL/kg) significantly inhibited gastric ulcers in rats that induced by water immersion stress (92.4 and 96.6%, respectively), HCl/ethanol (74.8 and 73.3%, respectively) and indomethacin (68.8 and 88.9%, respectively), while PFO-SM did not. PFO displayed potent analgesic, anti-inflammatory and anti-ulcer properties, while PFO-SM exerted only analgesic properties. Thus, Thai PFO and its functional drink offer potential benefits in treatment of analgesic, inflammatory diseases and gastric ulcer.