Publication: Relationship between nerve fiber layer hemorrhages and outcomes in central retinal vein occlusion
Issued Date
2020-05-01
Resource Type
ISSN
15525783
01460404
01460404
Other identifier(s)
2-s2.0-85085539603
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Investigative Ophthalmology and Visual Science. Vol.61, No.5 (2020)
Suggested Citation
Adrian Au, Assaf Hilely, Jackson Scharf, Frederic Gunnemann, Derrick Wang, Ismael Chehaibou, Claudio Iovino, Christelle Grondin, Marie Louise Farecki, Khalil Ghasemi Falavarjani, Nopasak Phasukkijwatana, Marco Battista, Enrico Borrelli, Riccardo Sacconi, Brittany Powell, Grant Hom, Tyler E. Greenlee, Thais F. Conti, Gerardo Ledesma-Gil, Mehmet Yasin Teke, Netan Choudhry, Adrian T. Fung, Valerie Krivosic, Jiwon Baek, Mee Yon Lee, Yoshimi Sugiura, Giuseppe Querques, Enrico Peiretti, Richard Rosen, Won Ki Lee, Lawrence A. Yannuzzi, Dinah Zur, Anat Loewenstein, Daniel Pauleikhoff, Rishi Singh, Yasha Modi, Jean Pierre Hubschman, Michael Ip, Srini Vas Sadda, K. Bailey Freund, David Sarraf Relationship between nerve fiber layer hemorrhages and outcomes in central retinal vein occlusion. Investigative Ophthalmology and Visual Science. Vol.61, No.5 (2020). doi:10.1167/IOVS.61.5.54 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/58198
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Title
Relationship between nerve fiber layer hemorrhages and outcomes in central retinal vein occlusion
Author(s)
Adrian Au
Assaf Hilely
Jackson Scharf
Frederic Gunnemann
Derrick Wang
Ismael Chehaibou
Claudio Iovino
Christelle Grondin
Marie Louise Farecki
Khalil Ghasemi Falavarjani
Nopasak Phasukkijwatana
Marco Battista
Enrico Borrelli
Riccardo Sacconi
Brittany Powell
Grant Hom
Tyler E. Greenlee
Thais F. Conti
Gerardo Ledesma-Gil
Mehmet Yasin Teke
Netan Choudhry
Adrian T. Fung
Valerie Krivosic
Jiwon Baek
Mee Yon Lee
Yoshimi Sugiura
Giuseppe Querques
Enrico Peiretti
Richard Rosen
Won Ki Lee
Lawrence A. Yannuzzi
Dinah Zur
Anat Loewenstein
Daniel Pauleikhoff
Rishi Singh
Yasha Modi
Jean Pierre Hubschman
Michael Ip
Srini Vas Sadda
K. Bailey Freund
David Sarraf
Assaf Hilely
Jackson Scharf
Frederic Gunnemann
Derrick Wang
Ismael Chehaibou
Claudio Iovino
Christelle Grondin
Marie Louise Farecki
Khalil Ghasemi Falavarjani
Nopasak Phasukkijwatana
Marco Battista
Enrico Borrelli
Riccardo Sacconi
Brittany Powell
Grant Hom
Tyler E. Greenlee
Thais F. Conti
Gerardo Ledesma-Gil
Mehmet Yasin Teke
Netan Choudhry
Adrian T. Fung
Valerie Krivosic
Jiwon Baek
Mee Yon Lee
Yoshimi Sugiura
Giuseppe Querques
Enrico Peiretti
Richard Rosen
Won Ki Lee
Lawrence A. Yannuzzi
Dinah Zur
Anat Loewenstein
Daniel Pauleikhoff
Rishi Singh
Yasha Modi
Jean Pierre Hubschman
Michael Ip
Srini Vas Sadda
K. Bailey Freund
David Sarraf
Other Contributor(s)
Hazrate Rasoole Akram Hospital
VA Greater Los Angeles Healthcare System
Università degli Studi di Cagliari
The University of Sydney
NYU Grossman School of Medicine
Hôpital Lariboisiere AP-HP
Cleveland Clinic Foundation
Jules Stein Eye Institute
Vitreous Retina Macula Consultants of New York
Doheny Eye Institute
Faculty of Medicine, Siriraj Hospital, Mahidol University
Università Vita-Salute San Raffaele
New York Eye and Ear Infirmary
Tel Aviv University, Sackler Faculty of Medicine
The Catholic University of Korea
St. Franziskus-Hospital Münster
Vitreous Retina Macula Specialists of Toronto
Ankara Ulucanlar Eye Training and Research Hospital
Nune Eye Hospital
VA Greater Los Angeles Healthcare System
Università degli Studi di Cagliari
The University of Sydney
NYU Grossman School of Medicine
Hôpital Lariboisiere AP-HP
Cleveland Clinic Foundation
Jules Stein Eye Institute
Vitreous Retina Macula Consultants of New York
Doheny Eye Institute
Faculty of Medicine, Siriraj Hospital, Mahidol University
Università Vita-Salute San Raffaele
New York Eye and Ear Infirmary
Tel Aviv University, Sackler Faculty of Medicine
The Catholic University of Korea
St. Franziskus-Hospital Münster
Vitreous Retina Macula Specialists of Toronto
Ankara Ulucanlar Eye Training and Research Hospital
Nune Eye Hospital
Abstract
Copyright 2020 The Authors PURPOSE. To evaluate the depth and pattern of retinal hemorrhage in acute central retinal vein occlusion (CRVO) and to correlate these with visual and anatomic outcomes. METHODS. Retinal hemorrhages were evaluated with color fundus photography and fluorescein angiography at baseline and follow-up. Snellen visual acuity (VA), central foveal thickness (CFT), extent of retinal ischemia, and development of neovascularization were analyzed. RESULTS. 108 eyes from 108 patients were evaluated. Mean age was 63.6 ± 16.1 years with a predilection for the right eye (73.1%). Average follow-up was 17.2 ± 19.2 months. Mean VA at baseline was 20/126 and 20/80 at final follow-up. Baseline (P = 0.005) and final VA (P = 0.02) in eyes with perivascular nerve fiber layer (NFL) hemorrhages were significantly worse than in eyes with deep hemorrhages alone. Baseline CFT was greater in the group with perivascular hemorrhages (826 ± 394 μm) compared to the group with deep hemorrhages alone (455 ± 273 μm, P < 0.001). The 10 disc areas of retinal ischemia was more common in patients with perivascular (80.0%) and peripapillary (31.3%) versus deep hemorrhages alone (16.1%, P < 0.001). Neovascularization of the iris was more common, although this differrence was not significant, in the groups with peripapillary (14.3%) and perivascular (2.0%) NFL versus deep hemorrhages alone (0.0%). CONCLUSIONS. NFL retinal hemorrhages at baseline correlate with more severe forms of CRVO, with greater macular edema, poorer visual outcomes, and greater risk of ischemia and neovascularization. This may be related to the organization of the retinal capillary plexus. The depth and pattern of distribution of retinal hemorrhages in CRVO may provide an easily identifiable early biomarker of CRVO prognosis.