Publication: Hemodynamics in the mouse aortic arch as assessed by MRI, ultrasound, and numerical modeling
Issued Date
2007-02-01
Resource Type
ISSN
15221539
03636135
03636135
Other identifier(s)
2-s2.0-33846944350
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Mahidol University
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SCOPUS
Bibliographic Citation
American Journal of Physiology - Heart and Circulatory Physiology. Vol.292, No.2 (2007)
Suggested Citation
Akiva Feintuch, Permyos Ruengsakulrach, Amy Lin, Ji Zhang, Yu Qing Zhou, Jonathon Bishop, Lorinda Davidson, David Courtman, F. Stuart Foster, David A. Steinman, R. Mark Henkelman, C. Ross Ethier Hemodynamics in the mouse aortic arch as assessed by MRI, ultrasound, and numerical modeling. American Journal of Physiology - Heart and Circulatory Physiology. Vol.292, No.2 (2007). doi:10.1152/ajpheart.00796.2006 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/24255
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Title
Hemodynamics in the mouse aortic arch as assessed by MRI, ultrasound, and numerical modeling
Abstract
Mice are widely used to study arterial disease in humans, and the pathogenesis of arterial diseases is known to be strongly influenced by hemodynamic factors. It is, therefore, of interest to characterize the hemodynamic environment in the mouse arterial tree. Previous measurements have suggested that many relevant hemodynamic variables are similar between the mouse and the human. Here we use a combination of Doppler ultrasound and MRI measurements, coupled with numerical modeling techniques, to characterize the hemodynamic environment in the mouse aortic arch at high spatial resolution. We find that the hemodynamically induced stresses on arterial endothelial cells are much larger in magnitude and more spatially uniform in the mouse than in the human, an effect that can be explained by fluid mechanical scaling principles. This surprising finding seems to be at variance with currently accepted models of the role of hemodynamics in atherogenesis and the known distribution of atheromatous lesions in mice. Copyright © 2007 the American Physiological Society.