Publication: Butenolides from Streptomyces albus J1074 act as external signals to stimulate avermectin production in Streptomyces avermitilis
Issued Date
2018-05-01
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ISSN
10985336
00992240
00992240
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2-s2.0-85045516598
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Mahidol University
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SCOPUS
Bibliographic Citation
Applied and Environmental Microbiology. Vol.84, No.9 (2018)
Suggested Citation
Thao Bich Nguyen, Shigeru Kitani, Shuichi Shimma, Takuya Nihira Butenolides from Streptomyces albus J1074 act as external signals to stimulate avermectin production in Streptomyces avermitilis. Applied and Environmental Microbiology. Vol.84, No.9 (2018). doi:10.1128/AEM.02791-17 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/44762
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Title
Butenolides from Streptomyces albus J1074 act as external signals to stimulate avermectin production in Streptomyces avermitilis
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Abstract
© 2018 American Society for Microbiology. In streptomycetes, autoregulators are important signaling compounds that trigger secondary metabolism, and they are regarded as Streptomyces hormones based on their extremely low effective concentrations (nM) and the involvement of specific receptor proteins. Our previous distribution study revealed that butenolidetype Streptomyces hormones, including avenolide, are a general class of signaling molecules in streptomycetes and that Streptomyces albus strain J1074 may produce butenolide-type Streptomyces hormones. Here, we describe metabolite profiling of a disruptant of the S. albus aco gene, which encodes a key biosynthetic enzyme for butenolide-type Streptomyces hormones, and identify four butenolide compounds from S. albus J1074 that show avenolide activity. The compounds structurally resemble avenolide and show different levels of avenolide activity. A dual-culture assay with imaging mass spectrometry (IMS) analysis for in vivo metabolic profiling demonstrated that the butenolide compounds of S. albus J1074 stimulate avermectin production in another Streptomyces species, Streptomyces avermitilis, illustrating the complex chemical interactions through interspecies signals in streptomycetes.