Publication: Nasopharyngeal carcinoma signaling pathway: An update on molecular biomarkers
Issued Date
2012-04-19
Resource Type
ISSN
16878884
16878876
16878876
Other identifier(s)
2-s2.0-84859783500
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal of Cell Biology. (2012)
Suggested Citation
Warut Tulalamba, Tavan Janvilisri Nasopharyngeal carcinoma signaling pathway: An update on molecular biomarkers. International Journal of Cell Biology. (2012). doi:10.1155/2012/594681 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/13754
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Title
Nasopharyngeal carcinoma signaling pathway: An update on molecular biomarkers
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Abstract
Nasopharyngeal carcinoma (NPC) is an uncommon cancer, which has a distinctive ethnic and geographic distribution. Etiology of NPC is considered to be related with a complex interaction of environmental and genetic factors as well as Epstein-Barr virus infection. Since NPC is located in the silent painless area, the disease is usually therefore diagnosed at the advanced stages; hence early detection of NPC is difficult. Furthermore, understanding in molecular pathogenesis is still lacking, pondering the identification of effective prognostic and diagnostic biomarkers. Dysregulation of signaling molecules in intracellular signal transduction, which regulate cell proliferation, apoptosis, and adhesion, underlines the basis of NPC pathogenesis. In this paper, the molecular signaling pathways in the NPC are discussed for the holistic view of NPC development and progression. The important insights toward NPC pathogenesis may offer strategies for identification of novel biomarkers for diagnosis and prognosis. Copyright 2012 Warut Tulalamba and Tavan Janvilisri.
